Project description:We showed that KLF-1 is needed for longevity of isp-1(qm150);ctb-1(qm189) mutant specifically in adulthood. We aimed to determine the expression changes that occur specifically upon adulthood klf-1 RNAi compared to developmental RNAi that did not affect the lifespan of isp-1(qm150);ctb-1(qm189) mutant.
Project description:Comparison of gene expression profiles from C. elegans mutant strain CF1038 treated with L4440 and K02A4.1 RNAi and C. elegans mutant strain TU3311 treated with L4440 and B0412.2 RNAi for 5 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)
Project description:This dataset contains the transcriptome profiling results of Caenorhabditis elegans under pitp−1 regulation. The experiment was designed to identify the transcriptional mechanisms underlying the pitp−1 suppression-mediated lifespan extension. Transcriptomic analysis was performed on pitp−1 mutant and pitp−1(RNAi)-treated worms at Day 3 of Adulthood (D3A). Bioinformatic pathway analysis (IPA) of the resulting differential expression profiles revealed a significant and coordinated downregulation of genes associated with the IIS (Insulin/IGF-1 Signaling) and TOR signaling pathways. This dataset therefore provides key molecular insight into how PITP−1 transcriptionally affects the major longevity regulatory networks.
