Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Identification of H3N2 specific antibodies cross-reacting with H7 strains

ABSTRACT: Identification of H3N2 specific antibodies cross-reacting with H7 strains

PROVIDER: PRJNA267189 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Identification of H3N2 specific antibodies cross-reacting with H7 strains

Project description:Binding profile of H3N2 hemagglutinin (HA) reactive antibodies for various H3N2 and H7 HA proteins

2014-11-14 | GSE63249 | GEO

Transcriptomes of genetically distinct E. coli O157:H7 strains

Project description:Transcriptomes of 24 clinical strains of E. coli O157:H7 that differ phylogenetically and by Shiga toxin profiles were compared after 30 min co-incubation with epithelial cells.

2010-07-22 | GSE20397 | GEO

The Role of LVV-H7 in Alcohol-Induced Reward Mechanisms

Project description:Hemorphins are short peptides generated during cleavage of the hemoglobin chains but alpha chain, with various functions in different systems and tissues in both physiology and pathophysiology. The main purpose of this study was to establish the role of LVV-H7 in the mechanism of alcohol dependence. LVV-hemorphin 7 (LVV-H7) is released at higher concentrations in the presence of alcohol in vitro. Therefore, we predicted that alcohol intake can change the level of LVV-H7. We have accomplished behavioral tests in animal studies, along with proteomic analysis of the CNS tissues of alcohol addicted rats to verify the correlation of LVV-H7 level and ethanol dependence. We have also confirmed the BBB permeability of synthesized LVV-H7, as well as an inhibitor of its releasing enzyme- pepstatin using fluorescent microscopy. We have found a dose-dependent correlation between LVV-H7 and the time spent by rats in the drug-associated compartment using CPP test. Utilizing mass spectrometry-based methods we identified protein binding targets of LVV-H7 in the CNS tissue of addicted rats, along with the LVV-H7 degrading enzymes. The interpretation of the obtained results reveals the substantial role of LVV-H7 in the mechanism of alcohol dependence.

2025-09-05 | PXD036448 | Pride

Cross-reacting antibodies enhance dengue virus infection in humans.

Project description:Dengue virus co-circulates as four serotypes, and sequential infections with more than one serotype are common. One hypothesis for the increased severity seen in secondary infections is antibody-dependent enhancement (ADE) leading to increased replication in Fc receptor-bearing cells. In this study, we have generated a panel of human monoclonal antibodies to dengue virus. Antibodies to the structural precursor-membrane protein (prM) form a major component of the response. These antibodies are highly cross-reactive among the dengue virus serotypes and, even at high concentrations, do not neutralize infection but potently promote ADE. We propose that the partial cleavage of prM from the viral surface reduces the density of antigen available for viral neutralization, leaving dengue viruses susceptible to ADE by antibody to prM, a finding that has implications for future vaccine design.

| S-EPMC3837288 | biostudies-literature

Brevibacillus sp. H7 strain:H7

Project description:Brevibacillus sp. H7 strain:H7 Genome sequencing

| PRJNA1162698 | ENA

Influenza H3N2 infection of the Collaborative Cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice (blood)

Project description:To determine if genetic background can modulate severity of an infection, we studied the host responses to influenza infections in the eight genetically highly diverse Collaborative Cross (CC) founder mice. The CC founder (C57BL/6J, 129S1/SvlmJ, CAST/EiJ, PWK/PhJ) were intranasally infected with influenza A/HK/01/68 (H3N2) with 20Î¼l virus solution (1x101 ffu) or mock infected (with PBS). After infection lung was collected at different time points (mock_d3), d3, d5).

2015-12-31 | E-GEOD-74073 | biostudies-arrayexpress

Influenza H3N2 infection of the Collaborative Cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice (lung)

2015-12-31 | E-GEOD-74074 | biostudies-arrayexpress

Hebeloma cylindrosporum h7 strain:h7

Project description:Hebeloma cylindrosporum h7 strain:h7 Genome sequencing and assembly

| PRJNA207849 | ENA

Hydrogenophaga sp. H7 strain:H7

Project description:Hydrogenophaga sp. H7 strain:H7 Genome sequencing and assembly

| PRJNA331085 | ENA

Hebeloma cylindrosporum h7 strain:h7

Project description:Hebeloma cylindrosporum h7 transcriptome

| PRJNA586561 | ENA