Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA270502 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:The effect of calorie restriction from two to 12 months of age was evaluated in gastrocnemius muscle in both wildtype mice as well as Sirt3 knockout mice The dietary intervention was initiated at 2 months of age and continued until 12 months of age
2021-11-25 | GSE64229 | GEO
Project description:Gene expression in mouse gastrocnemius muscle in response to short-term calorie restriction
| PRJNA304624 | ENA
Project description:Gene expression profile of gastrocnemius muscle from D257A mice
2015-09-15 | E-GEOD-21189 | ExpressionAtlas
Project description:Skeletal muscle PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction.
2015-09-22 | E-GEOD-34773 | ExpressionAtlas
Project description:In utero undernutrition is associated with obesity and insulin resistance, although its effect on skeletal muscle remains poorly defined. We report that, in mice, adult offspring from undernourished dams have decreased energy expenditure, decreased skeletal muscle mitochondrial content, and altered energetics in isolated mitochondria and permeabilized muscle fibers. Strikingly, when these mice are put on a 40% calorie restricted diet they lose half as much weight as calorie restricted controls. Our results reveal for the first time that in utero undernutrition alters metabolic physiology having a profound effect on skeletal muscle energetics and response to calorie restriction in adulthood. We have used a mouse model of low birth weight generated through 50% food restriction of mouse dams during the third week of gestation. We have studied in utero food restricted offspring and control offspring that were not food restricted in utero in both the ad libitum and calorie restricted states. Gene expression profiling was performed on tibialis anterior muscle from 8 mice per group, pooled in pairs.
2014-08-01 | E-GEOD-53520 | biostudies-arrayexpress
Project description:In utero undernutrition is associated with obesity and insulin resistance, although its effect on skeletal muscle remains poorly defined. We report that, in mice, adult offspring from undernourished dams have decreased energy expenditure, decreased skeletal muscle mitochondrial content, and altered energetics in isolated mitochondria and permeabilized muscle fibers. Strikingly, when these mice are put on a 40% calorie restricted diet they lose half as much weight as calorie restricted controls. Our results reveal for the first time that in utero undernutrition alters metabolic physiology having a profound effect on skeletal muscle energetics and response to calorie restriction in adulthood.
2014-08-01 | GSE53520 | GEO
Project description:The effect of a short-term calorie restricted diet was evaluated in gastrocnemius muscle (GASTROC) in seven strains of mice The dietary intervention was initiated at 8 weeks of age and continued until 22 weeks of age
2017-05-31 | GSE75571 | GEO
Project description:Calorie restriction suppresses age-dependent hippocampal transcriptional signatures.
2019-05-14 | E-GEOD-69952 | ExpressionAtlas
Project description:Calorie restriction is a major intervention consistently demonstrated to retard aging and delay age-associated diseases. A novel micronutrient blend, a putative calorie restriction mimetic, was developed based on a screening tool we previously described. Whole transcriptomic analysis was examined in brain cortex, skeletal muscle and heart in three groups of mice: old controls (30 months), old + calorie restriction and old + novel micronutrient blend. The micronutrient blend elicited transcriptomic changes in a manner similar to those in the calorie-restricted group and unique from those in the control group. Subgroup analysis revealed that nuclear hormone receptor, proteasome complex and angiotensinogen genes, all of which are known to be directly related to the aging process, were the most affected by the micronutrient blend and by calorie restriction. Thus, these three genes may be considered master regulators of the favorable effects of calorie restriction and of the micronutrient blend. Based on the calorie restriction mimetic effects on transcriptomics, it was hypothesized that the micronutrient blend would promotes longevity and vitality. To test this hypothesis, a functional analysis in C. Elegans was used to examine the effects of the micronutrient blend on longevity and biomarkers of vitality. Results indicate that feeding C. Elegans the micronutrient blend increased longevity as well as vitality. Further studies are required to confirm that the calorie restriction mimicking benefits described here are elicited by the micronutrient blend in humans.
2020-11-05 | E-MTAB-8506 | biostudies-arrayexpress
Project description:A novel micronutrient blend mimics calorie restriction transcriptomics in multiple tissues of mice and increases life and healthspan in C. Elegans
2020-01-07 | E-MTAB-8506 | ExpressionAtlas