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ABSTRACT: Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation

PROVIDER: PRJNA275413 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR1803390.fastq.gz	Fastqsanger.gz
	SRR1803400.fastq.gz	Fastqsanger.gz
	SRR1803540.fastq.gz	Fastqsanger.gz
	SRR1803550.fastq.gz	Fastqsanger.gz
	SRR1803560.fastq.gz	Fastqsanger.gz

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Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life

Project description:Neonates often generate incomplete immunity against intracellular pathogens, although the mechanism of this defect is poorly understood. An important question is whether the impaired development of memory CD8+ T cells in neonates is due to an immature priming environment or lymphocyte-intrinsic defects. Here we show that neonatal and adult CD8+ T cells adopted different fates when responding to equal amounts of stimulation in the same host. While adult CD8+ T cells differentiated into a heterogeneous pool of effector and memory cells, neonatal CD8+ T cells preferentially gave rise to short-lived effector cells and exhibited a distinct gene expression profile. Surprisingly, impaired neonatal memory formation was not due to a lack of responsiveness, but instead because neonatal CD8+ T cells expanded more rapidly than adult cells and quickly became terminally differentiated. Collectively, these findings demonstrate that neonatal CD8+ T cells exhibit an imbalance in effector and memory CD8+ T cell differentiation, which impairs the formation of memory CD8+ T cells in early life mRNA profiles of effector CD8+ T cells from neonatal and adult mice

2014-05-13 | E-GEOD-56575 | biostudies-arrayexpress

Mus musculus

Project description:Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [RNA-seq]

| PRJNA275416 | ENA

Mus musculus

Project description:Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [miRNA-Seq]

| PRJNA297054 | ENA

Homo sapiens

Project description:Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [human miRNA-seq]

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Mus musculus

Project description:Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [3'UTR-seq]

| PRJNA275417 | ENA

Mus musculus

Project description:Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [small-RNA seq]

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Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [small-RNA seq]

Project description:Neonates are intrinsically defective at creating memory CD8+ T cells in response to infection with intracellular pathogens. Here we investigated differential of small RNAs, transcription factors, and chemokine receptors regulation in neonates as compared to adults before and during infection. We found that prior to infection, naïve cells have a different expression profile for many microRNAs, and gene targets of these microRNAs show widespread expression differences. These targets and other changes in gene expression in naïve cells result in neonatal cells that get activated more easily, express chemokine receptors that home to sites of infection, and are less protected from apoptosis during contraction. As a result, changes in neonatal naïve cells drive effector cell terminal differentiation at the expense of creating long-lived memory cells. Small RNAs were sequenced from adult and neonatal CD8+ T cells before and during infection

2015-09-24 | E-GEOD-65920 | biostudies-arrayexpress

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [human miRNA-seq]

2015-09-24 | E-GEOD-66650 | biostudies-arrayexpress

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [3'UTR-seq]

Project description:Neonates are intrinsically defective at creating memory CD8+ T cells in response to infection with intracellular pathogens. Here we investigated differential of small RNAs, transcription factors, and chemokine receptors regulation in neonates as compared to adults before and during infection. We found that prior to infection, naïve cells have a different expression profile for many microRNAs, and gene targets of these microRNAs show widespread expression differences. These targets and other changes in gene expression in naïve cells result in neonatal cells that get activated more easily, express chemokine receptors that home to sites of infection, and are less protected from apoptosis during contraction. As a result, changes in neonatal naïve cells drive effector cell terminal differentiation at the expense of creating long-lived memory cells. PolyA RNA was selected and sequenced from adult and neonatal CD8+ T cells before and during infection

2015-09-24 | E-GEOD-65921 | biostudies-arrayexpress

Neonatal naïve CD8+ T cells have effector-like gene expression that prevents memory cell formation [RNA-seq]

Project description:Neonates are intrinsically defective at creating memory CD8+ T cells in response to infection with intracellular pathogens. Here we investigated differential of small RNAs, transcription factors, and chemokine receptors regulation in neonates as compared to adults before and during infection. We found that prior to infection, naïve cells have a different expression profile for many microRNAs, and gene targets of these microRNAs show widespread expression differences. These targets and other changes in gene expression in naïve cells result in neonatal cells that get activated more easily, express chemokine receptors that home to sites of infection, and are less protected from apoptosis during contraction. As a result, changes in neonatal naïve cells drive effector cell terminal differentiation at the expense of creating long-lived memory cells. total RNAs were sequenced from adult and neonatal CD8+ T cells before and during infection

2015-09-24 | E-GEOD-65922 | biostudies-arrayexpress

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