Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rattus norvegicus

ABSTRACT: Motivated cocaine seeking lead to transgenerational epigenetic inheritance of vulnerability to cocaine addiction

PROVIDER: PRJNA293970 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR2184200_1.fastq.gz	Fastqsanger.gz
	SRR2184200_2.fastq.gz	Fastqsanger.gz
	SRR2184210_1.fastq.gz	Fastqsanger.gz
	SRR2184210_2.fastq.gz	Fastqsanger.gz
	SRR2184201_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 34

Similar Datasets

Motivated cocaine seeking lead to transgenerational epigenetic inheritance of vulnerability to cocaine addiction

Project description:Familial transmission and high heritability of liability for drug abuse has been demonstrated by large scale epidemiological and twin studies, but the role of pre-existing susceptibility to addiction is still not clear. Our data show that F1 and F2 offspring sired by rats with high motivation for drug reinforcement and drug intake during cocaine self-administration maintained their ancestor’s addict-like behavior. This paternal transmission of drug addiction is an acquired trait that is dependent on cocaine induced high motivation in F0. Reduced representation bisulfite sequencing of F0 and F1 sperm DNA reveal a few persistent epigenetic changes in genes that critically regulate early development and morphogenesis. These epigenetic traits may underlie alterations in the neurological basis that lead to the transmission of cocaine motivation. Our results reveal the epigenetic transgenerational inheritance of drug craving and provide a potential etiology in cocaine abuse vulnerability.

2017-03-17 | GSE72401 | GEO

Rattus norvegicus

Project description:Environmentally Induced Epigenetic Transgenerational Inheritance of Somatic Transcriptomes

| PRJNA151967 | ENA

Rattus norvegicus

Project description:Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease [NimbleGen]

| PRJNA255458 | ENA

Rattus norvegicus

Project description:Environmental Toxicants Induce Epigenetic Transgenerational Inheritance of Ovarian Disease [Affymetrix]

| PRJNA148923 | ENA

Rattus norvegicus

Project description:Environmentally Induced Epigenetic Transgenerational Inheritance of Sperm Epimutations Promotes Genetic Mutations [CGH]

| PRJNA261281 | ENA

Rattus norvegicus

Project description:Dioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm Epimutations

| PRJNA255886 | ENA

Rattus norvegicus

Project description:Environmentally Induced Epigenetic Transgenerational Inheritance of Sperm Epimutations Promotes Genetic Mutations [MeDIP-Chip]

| PRJNA264085 | ENA

Dopaminylation of Histone H3 in Ventral Tegmental Area Regulates Cocaine-seeking

Project description:Vulnerability to relapse during periods of attempted abstinence from cocaine use is hypothesized to result from rewiring of brain reward circuitries, particularly ventral tegmental area (VTA) dopamine neurons. How cocaine exposures act on midbrain dopamine neurons to precipitate addiction-relevant changes in gene expression is unclear. We found that histone H3 glutamine 5 dopaminylation (H3Q5dop) plays a critical role in cocaine-induced transcriptional plasticity in midbrain. Rats undergoing withdrawal from cocaine showed an accumulation of H3Q5dop in VTA. By reducing H3Q5dop in VTA during withdrawal, we reversed cocaine-mediated gene expression changes, attenuated cue-induced dopamine release in nucleus accumbens and reduced cocaine-seeking behavior. These findings establish a neurotransmission-independent role for nuclear dopamine in relapse-related transcriptional plasticity in VTA.

2020-05-19 | GSE124055 | GEO

Epigenetic control of an auxiliary subunit of sodium voltage-gated channels regulates the strength of drug-cue associations and relapse-like cocaine seekingEpigenetic control of an auxiliary subunit of sodium voltage-gated channels regulates the strength of drug-cue associations and relapse-like cocaine seeking

Project description:Repeated use of illicit drugs produces long-lasting and prepotent drug-cue associations that increase vulnerability for relapse in individuals with a substance use disorder. Epigenetic factors like histone deacetylase 5 (HDAC5) play a key role in regulating the formation of drug-cue associations, but the underlying mechanisms remain unclear. We show here that two conserved cysteines located near HDAC5’s catalytic domain are required for its intrinsic deacetylase activity, and that HDAC5’s deacetylase activity is required in nucleus accumbens (NAc) medium spiny neurons (MSNs) to limit their intrinsic excitability and relapse-like cue-reinstated cocaine seeking. Moreover, we show that HDAC5 limits NAc MSN firing rate and cue-reinstated cocaine seeking by deacetylase-dependent repression of Scn4b, a novel HDAC5 target gene that encodes an auxiliary subunit of voltage-gated ion channels. Taken together, our data suggest that epigenetic control of NAc Scn4b governs the plasticity underlying formation of drug-cue associations through modulation of NAc MSN intrinsic excitability.

2025-02-18 | PXD055005 | Pride

Rattus norvegicus

Project description:Atrazine Induced Epigenetic Transgenerational Inheritance of Disease, Lean Phenotype and Sperm Epimutation Pathology Biomarkers

| PRJNA385883 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data