Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A transcription factor pulse can prime chromatin for heritable transcriptional memory

ABSTRACT: A transcription factor pulse can prime chromatin for heritable transcriptional memory

PROVIDER: PRJNA294144 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR2192250.fastq.gz	Fastqsanger.gz
	SRR2192260.fastq.gz	Fastqsanger.gz
	SRR2192280.fastq.gz	Fastqsanger.gz
	SRR2192290.fastq.gz	Fastqsanger.gz
	SRR2192251.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 35

Similar Datasets

A transcription factor pulse can prime chromatin for heritable transcriptional memory [ChIPseq]

Project description:To investigate the epigenetic control of long-term transcriptionnal memory (LTTM) we used a trans-differentiation system where Bcell are reprogramed into macrophages upon induction of the transcription factor Cebpa. We performed ChIPseq in untreated Bcells, after 12h of Cebpa induction and after 6days of “wash” of Cebpa, to see if any proteins/histone marks are retained.

2016-12-21 | GSE72486 | GEO

A transcription factor pulse can prime chromatin for heritable transcriptional memory [RNAseq]

Project description:To indentify genes displaying long-term transcriptionnal memory (LTTM) we used a trans-differentiation system where Bcell are reprogramed into macrophages upon induction of the transcription factor Cebpa. We performed RNAseq in untreated Bcells, after 12h of Cebpa induction and after 6days of “wash” of Cebpa, to see if any genes respond more/faster in a second stimulation than in the first.

2016-12-21 | GSE72487 | GEO

A Transcription Factor Pulse Can Prime Chromatin for Heritable Transcriptional Memory.

Project description: Not available

| S-EPMC5288571 | biostudies-literature

A transcription factor pulse can prime chromatin for heritable transcriptional memory

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-12-21 | GSE72488 | GEO

Mus musculus

Project description:A transcription factor pulse can prime chromatin for heritable transcriptional memory [RNAseq]

| PRJNA294145 | ENA

Mus musculus

Project description:A transcription factor pulse can prime chromatin for heritable transcriptional memory [ChIPseq]

| PRJNA294146 | ENA

Widespread transcriptional memory shapes heritable states and functional heterogeneity in cancer and stem cells

Project description:Recent studies show that non-genetic heterogeneity, particularly through heritable cell states, shapes cancer evolution and developmental trajectories. However, single-cell snapshots lack temporal information to identify these states. We employ lineage-resolved single-cell transcriptomics to map heritable cell states that persist across divisions, distinguishing them from transient fluctuations. We uncover that heritable states are underpinned by widespread transcriptional memory, whereby heritable gene expression defines two classes of states: clustered states, characterized by clustered gene expression, and latent states, marked by non-clustered gene expression. This memory shows conservation across cell types and conditions and appears to be maintained by robust epigenetic mechanisms resistant to environmental perturbations. Functionally, memory genes predict critical behaviors including metastatic potential and lineage commitment, with latent-state genes often outperforming clustered-state genes. Our findings establish transcriptional memory as a potential basis of heritable cellular heterogeneity, providing a framework for understanding functional cellular variations across biological systems. A record of this paper’s transparent peer review process is included in the supplemental information.

2026-04-30 | GSE329158 | GEO

Widespread transcriptional memory shapes heritable states and functional heterogeneity in cancer and stem cells [RRBS]

2026-04-30 | GSE329335 | GEO

Widespread transcriptional memory shapes heritable states and functional heterogeneity in cancer and stem cells [RNA-Seq]

2026-04-30 | GSE329159 | GEO

Widespread transcriptional memory shapes heritable states and functional heterogeneity in cancer and stem cells [scRNA-seq]

2026-04-30 | GSE329336 | GEO