Project description:WhiB4 regulates expression of anti-oxidant genes and survival of Mtb in resposne to oxidaitve stress. Thus, we did microarray upon exposure to 0.25 mM CHP for Wt Mtb and MtbΔwhiB4 strain complemented with whiB4 gene to study the restoration of gene expression to wild type levels.
Project description:Transcriptional profiling of M.tuberculosis to 10 mM vitamin C at 0.25, 0.5, 1, 2 , 4, 8 and 24 h compared to gene expression profile of untreated M. tuberculosis culture (0 h).
Project description:WhiB4 regulates expression of anti-oxidant genes and its own expression was shown to be down-regulated upon exposure to oxidatants like CHP. Further MtbΔwhiB4 was shown to survive better under oxidaitve stress. Thus, we did microarray upon exposure to 0.25 mM CHP to study comprehensively the WhiB4 regulon under oxidative stress.
Project description:To understand the response of M. tuberculosis (MTB) to the drug BTZ043, we performed transcriptomics on MTB bacilli exposed to the drug.
Project description:To understand the response of M. tuberculosis (MTB) to the drug dapsone, we performed transcriptomics on MTB bacilli exposed to the drug.
Project description:To understand the response of M. tuberculosis (MTB) to the drug verapamil, we performed transcriptomics on MTB bacilli exposed to the drug.
Project description:To understand the response of M. tuberculosis (MTB) to the drug sutezolid, we performed transcriptomics on MTB bacilli exposed to the drug.
