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Homo sapiens

ABSTRACT: ATAC-seq data from EB-HSPC after AM580 treatment compared to DMSO-treated EB

PROVIDER: PRJNA308423 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3095971_1.fastq.gz	Fastqsanger.gz
	SRR3095971_2.fastq.gz	Fastqsanger.gz
	SRR3095972_1.fastq.gz	Fastqsanger.gz
	SRR3095972_2.fastq.gz	Fastqsanger.gz
	SRR3095973_1.fastq.gz	Fastqsanger.gz

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Homo sapiens

Project description:RNA-seq expression data from EB-HSPC after AM580 treatment compated to DMSO-trated and FL-HSPCs

| PRJNA308426 | ENA

RNA-seq expression data from EB-HSPC after AM580 treatment compated to DMSO-trated and FL-HSPCs

Project description:RA signalling regulated endothelial to hematopoietic transition and HSC generation. EB- or FL-derived HSPC were profiled before (d0) or after (d6) 6 days of treatment with 0.2uM AM580 on OP9, and after 6 additional days of expandion of OP9 (d12) without treatment.

2016-05-16 | E-GEOD-76682 | biostudies-arrayexpress

Effect of T0901317, AM580 or T0901317+AM580 on monocyte gene expression

Project description:The aim of this study was to investigate the effect of T0901317 LXR agonist on Retinoic Acid Receptor (RAR) family gene expression. T0901317 alone increase RARalpha gene expression in monocytes and the effects of the co treatment of the cells with T0901317 and a specific RARalpha agonist (AM580) were further studied. For this monocytes were treated for 24h with DMSO or T0901317 to induce RARalpha expression and in a second step cells were treated or not with AM580 for another 24h period. Gene expression was analysed for all the treatments (T0901317, AM580 or T0901317+AM580) and we focussed on genes which expression was synergitically induced by the co treatment as compared to the cells treated either by T0901317 or AM580.

2009-10-01 | GSE13407 | GEO

Effect of T0901317, AM580 or T0901317+AM580 on monocyte gene expression

2010-04-08 | E-GEOD-13407 | biostudies-arrayexpress

ATAC-seq_experiment in RKO cell line under low replication stress

Project description:RKO cells were treated with low doses of aphidicolin (0.2µM) that inhibit replicative DNA polymerases and induce a mild replication stress. ATAC-seq data were analysed on control cells (DMSO) and after 16h of treatment with aphidicolin

2021-05-19 | GSE156552 | GEO

Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways.

Project description:In this study, the retinoid and vitamin D pathways were investigated in PMA-differentiated THP-1 cells treated with or without the RARa agonist, AM580, and/or the VDR agonist, 1,25-dihydroxyvitamin D3 (1,25-vitD or calcitriol), using global approaches. Binding regions of RARa and VDR were determined in PMA-differentiated THP-1 cells using chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq). The gene sets regulated by AM580 and/or 1,25-vitD were identified by RNA-sequencing (RNA-seq). The activity of the regulatory regions was determined by MED1 (a subunit of the Mediator complex) ChIP-seq and chromatin openness was measured using assay for transposase-accessible chromatin with sequencing (ATAC-seq).

2024-12-31 | GSE246309 | GEO

Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways.

2024-12-31 | GSE246308 | GEO

Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways.

2024-12-31 | GSE246307 | GEO

ATAC-Seq on Cohesin mutant HSPCs

Project description:Understanding the impact of cohesin mutations on HSPC chromatin structure We examined chromatin structure using ATAC-seq in CD34+ enriched-human HSPC that were transduced with either cohesin WT, mutant or empty vector controls

2015-11-03 | E-GEOD-73206 | biostudies-arrayexpress

Transcriptomic analysis of MERS-CoV infected Calu-3 cell with or without AM580 treatment

Project description:We report a broad spectrum antiviral drug AM580, RNA-Seq technology was used to compare the host gene mRNA expression between different groups to indicate the host pathway changes upon MERS-CoV infection and AM580 treatment.

2018-11-24 | GSE122876 | GEO

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