Project description:Pathological angiogenesis, the abnormal or excessive generation of blood vessels, plays an important role in many diseases including cancer, diabetic retinopathy, psoriasis, and arthritis. Additionally, increasing evidence supports the close linkage between angiogenesis and inflammation. Snake venoms are a rich natural source of biologically active molecules and carry rich potential for the discovery anti-angiogenic and anti-inflammatory modulators. Here, we isolated and purified a novel protein, ZK002, from the venom of the snake Deinagkistrodon acutus, and investigated its anti-angiogenic and anti-inflammatory activities and mechanisms.
Project description:This project employs 4D label-free mass spectrometry technology to conduct quantitative proteomics analysis on the venom of Deinagkistrodon acutus. It aims to identify the differentially expressed proteins in the venom, analyze their functional characteristics, and provide a theoretical basis for the research and development of snake venom-related biological products
