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Homo sapiens

ABSTRACT: Role of COP1 on MAP kinase transcriptional output in gastrointestinal stromal tumor

PROVIDER: PRJNA318528 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR3385200.fastq.gz	Fastqsanger.gz
	SRR3385210.fastq.gz	Fastqsanger.gz
	SRR3385201.fastq.gz	Fastqsanger.gz
	SRR3385211.fastq.gz	Fastqsanger.gz
	SRR3385202.fastq.gz	Fastqsanger.gz

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Role of COP1 on MAP kinase transcriptional output in melanoma

Project description:COP1 regulates MAP kinase dependent stability Pea3 transcription factors. We determined the role of COP1 in the regulation of MAP kianse transciptional output. We generated A375 melanoma cells with CRISPR/Cas9 mediated COP1 (gene symbol RFWD) knockout. We treated control sgEGFP and COP1 loss sgCOP1 cells with vehicle, 1 µM vemurafinib, or 5 nM trametinib for 8 hours and isolated RNA for sequencing.

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Role of COP1 on MAP kinase transcriptional output in gastrointestinal stromal tumor

Project description:COP1 regulates MAP kinase dependent stability Pea3 transcription factors. We determined the role of COP1 in the regulation of MAP kianse transciptional output. We transfected GIST882 cells with siRNA against a scrambled sequence and two sequences against COP1. We treated cells for 8 hours with vehicle or 100 nM PD0325901 in duplicate and isolated RNA for sequencing.

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Anatomic and transcriptional determinants of gastrointestinal stromal tumor

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Role of Cop1 on transcriptional output in 4T1 mouse triple negative breast cancer cells

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Role of Cop1 on chromatin accessibility in 4T1 mouse triple negative breast cancer cells

Project description:Cop1 regulates stability of transcription factors. We determined the role of Cop1 in the regulation of Cebpd transciptional output. We generated 4T1breast cancer cells with CRISPR/Cas9 mediated Cop1 (gene symbol RFWD2) knockout. We treated control sgRosa26 and sgCop1 cells with vehicle or IFNgamma (20ng/ml) for 24 hours and did ATAC-seq.

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MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor

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Project description:miRNA expression profile in GIST (gastrointestinal stromal tumor)

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Oncogenic SDH mutation underlies global epigenomic instability in gastrointestinal stromal tumor

Project description:We have discovered a striking connection between mitochondrial dysfunction and epigenomic instability, manifested by global biallelic DNA cytosine 5-methylation and loss of 5-hydroxymethycytosine within succinate dehydrogenase (SDH)-null gastrointestinal stromal tumors (GIST) relative to those bearing KIT or PDGFRA tyrosine kinase driver mutations. The duality of Krebs versus kinase molecular and epigenomic profiles in GIST provides compelling evidence linking mitochondrial process to nuclear structure and function and underscores an essential role for succinate metabolism in the maintenance of epigenomic programming and tumor suppression. Bisulfite-converted DNA from 144 samples were analyzed with the Illumina GoldenGate Methylation Cancer Panel I array.

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