Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Homo sapiens

ABSTRACT: Binding of basally expressed p53 in p53 wild-type nontumorigenic mammary epithelial MCF10A cells

PROVIDER: PRJNA318536 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR3452298.fastq.gz	Fastqsanger.gz
	SRR3452299.fastq.gz	Fastqsanger.gz

Items per page:

1 - 2 of 2

Similar Datasets

Homo sapiens

Project description:Identification of p53-regulated genes in breast epithelial cells using MCF10A with wild-type p53 or p53-null

| PRJNA386035 | ENA

E-GEOD-13274

Project description:Transcription profiling by array of human mammary epithelial cells infected with a recombinant adenoviral vector expressing a mutated HER2 inactivated for kinase function or wild type HER2

2025-01-24 | E-GEOD-13274 | ExpressionAtlas

E-GEOD-36082

Project description:Transcription profiling by array of ATM deficient human mammary epithelial cells

2025-01-24 | E-GEOD-36082 | ExpressionAtlas

E-GEOD-34055

Project description:Gene expression profile of SUMO knockout in human mammary epithelial cells

2025-01-24 | E-GEOD-34055 | ExpressionAtlas

E-GEOD-58948

Project description:Transcription profiling by array of small intestinal crypt base epithelial cells (Paneth cells) from wild-type and Nod2-/- mice

2014-10-16 | E-GEOD-58948 | ExpressionAtlas

E-MTAB-6384

Project description:RNASeq of Circadian clock genes form wild type and Bmal1 knockout mice of airway epithelial cells

2019-01-16 | E-MTAB-6384 | ExpressionAtlas

Downregulation of LATS kinases alters p53 to promote cell migration

Project description:p53 is a pivotal tumor suppressor and a major barrier against cancer. We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in non-transformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-?B subunit. Moreover, it partly shifts p53âs conformation and transcriptional output towards a state resembling cancer-associated p53 mutants, and endow p53 with the ability to promote cell migration. Notably, LATS1 and LATS2 are frequently downregulated in breast cancer; we propose that such downregulation might benefit cancer by converting p53 from a tumor suppressor into a tumor facilitator. MCF10A cells transfected with siRNA against LATS1/2 alone, p53 alone or LATS1/2 and p53 together. Two independent MCF10A batches provided biological replicates

2015-12-11 | E-GEOD-74493 | biostudies-arrayexpress

E-MEXP-1342

Project description:transcription profiling by array mouse mammary epithelial cells treated with TGF-beta to induce epithelial-to-mesenchymal transition

2015-10-22 | E-MEXP-1342 | ExpressionAtlas

E-GEOD-21309

Project description:Gene expression profile of lung epithelial cells cultured from normal tracheas of Gprc5a knockout and wild-type mice

2015-09-15 | E-GEOD-21309 | ExpressionAtlas

E-GEOD-13671

Project description:Expression data from mammary epithelial cells from BRCA1 mutation carriers and non BRCA1 mutation carriers

2025-01-24 | E-GEOD-13671 | ExpressionAtlas