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Schizosaccharomyces pombe

ABSTRACT: Expression data of nuclear mRNA export mutant rae1-167 cells

OTHER RELATED OMICS DATASETS IN: PXD004530

PROVIDER: PRJNA322255 | ENA |

REPOSITORIES: ENA

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Expression data of nuclear mRNA export mutant rae1-167 cells

Project description:rae1 is an essential gene and encodes one of nuclear pore complex. rae1-167 mutant cells show rapid accumulation of polyA-RNA in the nucleus at 36°C followed by protein accumulation, suggesting that accumulated nuclear mRNA influences nucelar cytooplasmic transport. We used microarrays to compare the overall gene expression of rae1-167 cells grown at 36°C with that at 25°C.

2017-05-18 | GSE81666 | GEO

A herpesvirus protein selectively inhibits cellular mRNA nuclear export

Project description:Nuclear export of mRNA is essential for eukaryotic cells to establish the flow of genetic information in the nucleus to protein synthesis in the cytoplasm. This transport process is highly regulated to ensure efficient and accurate gene expression. Viruses are well known for their ability to manipulate host gene expression. Here, we report that ORF10 of Kaposi’s sarcoma associated herpesvirus (KSHV), a nuclear DNA virus, inhibits mRNA export in a transcript-selective manner to control cellular gene expression. This export inhibitory effect of ORF10 requires the interaction with an RNA export factor, Rae1. Genome-wide analysis by RNA sequencing revealed the subset of cellular mRNAs whose nuclear export is blocked by ORF10. The 3’ untranslated regions (3’ UTRs) of ORF10-targeted transcripts confer their sensitivity to nuclear export inhibition by ORF10. In the context of KSHV replication, the interaction of ORF10 with Rae1 is important for the virus to express viral genes and produce infectious virions. Our results suggest that a nuclear replicating DNA virus can selectively interfere with RNA export through Rae1 to restrict host gene expression for optimal viral replication.

2016-10-18 | GSE82241 | GEO

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