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Wisconsin Longitudinal Study on Aging CIDR

ABSTRACT: Wisconsin Longitudinal Study on Aging CIDR

PROVIDER: PRJNA326558 | ENA |

REPOSITORIES: ENA

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Project description:Wisconsin Longitudinal Study on Aging CIDR

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Wisconsin Longitudinal Study on Aging

Project description:<p>The Wisconsin Longitudinal Study (WLS) is a long-term study of a random sample of men and women, who graduated from Wisconsin high schools in 1957, and their siblings. The WLS panel started out with a panel of 10,317 members from the class of 1957. Over time a second panel of 8,734 randomly selected siblings of the original graduate panel were recruited for the study. Of these combined panel members, 9,027 survived and contributed saliva for genetic analysis. Survey data were collected from the original respondents or their parents in 1957, 1964, 1975, 1992, 2004, and 2011, and from a selected sibling in 1977, 1994, 2005, and 2011. WLS data provide a detailed record of educational, social, psychological, economic, mental and physical health characteristics of a relatively homogeneous population that is almost entirely of Northern and Western European ancestry. Saliva was first collected in 2007-2008 by mail. Additional samples were collected in the course of home interviews that began in March 2010. </p>

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DNA methylation of longitudinal samples from The Swedish Adoption/Twin Study of Aging (SATSA)

Project description:The methylation data were measured from longitudinal blood samples to study the longitudinal change of methylation in association with age.

2018-10-20 | E-MTAB-7309 | biostudies-arrayexpress

RNA-seq of human fibroblasts during pseudo-longitudinal in-vitro aging and long-term Metformin or Rapamycin treatment

Project description:This dataset contains longitudinal transcriptomic profiles of human fibroblasts across in-vitro aging and pharmacological modulation with Metformin and Rapamycin. Longitudinal sampling of human cells is inherently challenging. Thus, we model aging in non-proliferative fibroblast cultures maintained at confluency, which recapitulate key transcriptomic signatures of in-vivo aging. Four female donor fibroblast lines were cultured for six months in a non-proliferative state, with sampling every 30 days to capture pseudo-longitudinal transcriptomic changes. Parallel cultures were treated with the anti-aging compounds Metformin or Rapamycin over the same period to assess their impact on age-associated transcriptional trajectories. We compare transcriptomic aging changes of in-vitro aging to a cohort of donors from 20-90 years. In addition, stable fibroblast lines expressing the neuronal transcription factors Ngn2 and Ascl1 were generated, enabling direct conversion of fibroblasts into induced neurons (iNs) at baseline and after six months of in-vitro aging. This design allows integrative analyses of transcriptomic aging signatures across cell states and pharmacological interventions.

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Associations of epigenetic aging and COVID-19: a 3-year longitudinal study

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CIDR: INTEGRAL Multiethnic Lung Cancer Study

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CIDR: INTEGRAL Multiethnic Lung Cancer Study

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RNA-seq of the killifish N.furzeri during normal aging (cross-sectional and longitudinal study) and treatment with rotenone

Project description:The study consists of three parts: 1) normal aging in liver and skin (cross-sectional); 2) treatment with rotenone in brain, liver and skin; 3) longitudinal study of 45 fish with different ages at their death measured at two different time points by fin clipping Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2015-12-03 | GSE66712 | GEO

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