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Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

ABSTRACT: Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

OTHER RELATED OMICS DATASETS IN: GSE86410PXD004956PXD004955

PROVIDER: PRJNA341704 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR4125040_1.fastq.gz	Fastqsanger.gz
	SRR4125040_2.fastq.gz	Fastqsanger.gz
	SRR4125050_1.fastq.gz	Fastqsanger.gz
	SRR4125050_2.fastq.gz	Fastqsanger.gz
	SRR4125060_1.fastq.gz	Fastqsanger.gz

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Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development [RNAseq]

Project description:Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes damaging secretions from the placenta that affect fetal development and whether a mitochondria-targeted antioxidant MitoQ might prevent this. Gestational hypoxia caused low birth-weight and changes in young adult offspring brain, mimicking those in human neuropsychiatric disease. Exposure of cultured neurons to fetal plasma or to secretions from the placenta or from model trophoblast barriers that had been exposed to altered oxygenation caused similar morphological changes. The secretions and plasma contained altered microRNAs whose targets were linked with changes in gene expression in the fetal brain and with human schizophrenia loci. Molecular and morphological changes in vivo and in vitro were prevented by a single dose of MitoQ bound to nanoparticles, which were shown to localise and prevent oxidative stress in the placenta but not in the fetus. We suggest the possibility of developing preventative treatments that target the placenta and not the fetus to reduce risk of psychiatric disease in later life.

2017-08-22 | GSE86408 | GEO

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development [microRNA]

2017-08-22 | GSE86346 | GEO

Treating the placenta with nanoparticles to prevent altered placental secretion and fetal development in response to hypoxia [Fetal Plasma]

Project description:Hypoxia-related pregnancy complications increase the risk of disease in the child in later life. No prevention is available. Previously we noted that a trophoblast barrier, an in vitro model of the placenta, reacted to oxidative stress by secreting factors that damage neighbouring cells. Application of mitochondrion-targeted antioxidant MitoQ prevented this. Here we tested the effects of MitoQ-bound nanoparticles on trophoblast barriers and in a rat model of gestational hypoxia.A single dose of MitoQ-nanoparticles, administered maternally before a hypoxic episode, reduced oxidative stress in the placental barrier without reaching the fetus and prevented changes to birthweight. MitoQ-nanoparticles further suppressed damaging signalling from the placental barriers. Altered signalling molecules in the fetal plasma and in conditioned media from rat placenta included changes to proteins with relevance to cardiovascular disease. We suggest as a future possibility, treatment of the placenta to prevent disease in the offspring in later life.

2017-08-22 | PXD004955 | Pride

Treating the placenta with nanoparticles to prevent altered placental secretion and fetal development in response to hypoxia [Conditioned Medium]

2017-08-22 | PXD004956 | Pride

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-08-22 | GSE86410 | GEO

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.

| S-EPMC5567270 | biostudies-literature

Maternal Probiotic Supplementation Effects on the Placenta-Brain Axis

Project description:The rate of probiotic usage by pregnant women in the US and Canada ranges from 1.3 to 3.6 %. Probiotic supplements are available without a prescription and have gained currency in treating a variety of ailment ranging from reducing risk of constipation, diarrhea, other gastrointestinal conditions, eczema, pre-term birth, and prevent adverse pregnancy outcomes, including gestational diabetes mellitus (GDM) and depression/anxiety. Three possible mechanisms by which maternal probiotic supplementation might influence the placenta are through 1) directly impacting possible bacteria residing in the placenta (placenta microbiome), 2) altering bacterial metabolites produced by gut microbiota within the mother that induce placental changes, and 3) maternal probiotics might affect the composition of the bacteria within the maternal gut that affects her immune cells and their responses to the heterologous placenta. For the second potential mechanism, bacterial metabolites that might influence placenta include short chain fatty acids (SCFAs), polyamines (PAs), and Vitamins B9 (Folic Acid) and 12 (Cobalamin), among others. This project aims to determine the effects maternal probiotic supplementation in mice might have on the fetal placenta. With the number of women taking over probiotic supplements increasing, further research is needed to determine how these bioactive agents may affect the placenta and health of the offspring.

2025-09-26 | GSE309308 | GEO

Differential expression of microRNAs in porcine placenta on gestational days 26 and 50

Project description:Affymetrix miRNA arrays were used to generate miRNA profiles in placenta of Meishan and Yorkshire pigs on stages of initiation (gestational day 26) and establishment (gestational day 50) of placental folds development. The study allowed for the determination of the miRNAs that were differentially expressed in porcine placenta on different gestational day. This study will provide the information to better understanding of the role miRNAs in porcine placental development.

2015-10-01 | GSE62996 | GEO

Rattus norvegicus

Project description:Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development [microRNA]

| PRJNA341488 | ENA

Rattus norvegicus

Project description:Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development [RNAseq]

| PRJNA341706 | ENA