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Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

OTHER RELATED OMICS DATASETS IN: PXD004956PRJNA341488PRJNA341704PXD004955PRJNA341706

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE86410 | GEO | 2017/08/22

SECONDARY ACCESSION(S): PRJNA341704

REPOSITORIES: GEO

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Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.

Project description: Not available

| S-EPMC5567270 | biostudies-literature

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development [RNAseq]

Project description:Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes damaging secretions from the placenta that affect fetal development and whether a mitochondria-targeted antioxidant MitoQ might prevent this. Gestational hypoxia caused low birth-weight and changes in young adult offspring brain, mimicking those in human neuropsychiatric disease. Exposure of cultured neurons to fetal plasma or to secretions from the placenta or from model trophoblast barriers that had been exposed to altered oxygenation caused similar morphological changes. The secretions and plasma contained altered microRNAs whose targets were linked with changes in gene expression in the fetal brain and with human schizophrenia loci. Molecular and morphological changes in vivo and in vitro were prevented by a single dose of MitoQ bound to nanoparticles, which were shown to localise and prevent oxidative stress in the placenta but not in the fetus. We suggest the possibility of developing preventative treatments that target the placenta and not the fetus to reduce risk of psychiatric disease in later life.

2017-08-22 | GSE86408 | GEO

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development [microRNA]

2017-08-22 | GSE86346 | GEO

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

Project description:Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

| PRJNA341704 | ENA

Treating the placenta with nanoparticles to prevent altered placental secretion and fetal development in response to hypoxia [Fetal Plasma]

Project description:Hypoxia-related pregnancy complications increase the risk of disease in the child in later life. No prevention is available. Previously we noted that a trophoblast barrier, an in vitro model of the placenta, reacted to oxidative stress by secreting factors that damage neighbouring cells. Application of mitochondrion-targeted antioxidant MitoQ prevented this. Here we tested the effects of MitoQ-bound nanoparticles on trophoblast barriers and in a rat model of gestational hypoxia.A single dose of MitoQ-nanoparticles, administered maternally before a hypoxic episode, reduced oxidative stress in the placental barrier without reaching the fetus and prevented changes to birthweight. MitoQ-nanoparticles further suppressed damaging signalling from the placental barriers. Altered signalling molecules in the fetal plasma and in conditioned media from rat placenta included changes to proteins with relevance to cardiovascular disease. We suggest as a future possibility, treatment of the placenta to prevent disease in the offspring in later life.

2017-08-22 | PXD004955 | Pride

Treating the placenta with nanoparticles to prevent altered placental secretion and fetal development in response to hypoxia [Conditioned Medium]

2017-08-22 | PXD004956 | Pride

Gestational hypoxia and epigenetic programming of brain development disorders.

Project description: Not available

| S-EPMC4262616 | biostudies-literature

Effects of prenatal hypoxia on fetal sheep heart development and proteomics analysis.

Project description: Not available

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Gestational disruptions in metabolic rhythmicity of the liver, muscle, and placenta affect fetal size.

Project description: Not available

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