Mus musculus
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA352967 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| SRR5007760.fastq.gz | Fastqsanger.gz | |||
| SRR5007770.fastq.gz | Fastqsanger.gz | |||
| SRR5007780.fastq.gz | Fastqsanger.gz | |||
| SRR5007790.fastq.gz | Fastqsanger.gz | |||
| SRR5007761.fastq.gz | Fastqsanger.gz |
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Project description:This study explored the interaction of early life and adult stress on transcriptional and chromosomal states in a 2x2 design. Male and female mice were subjected to early life stress (ELS) or were standard-reared (Std), were housed normally through adolescence, and were then exposed to 10 days of control (Ctl) or chronic social defeat stress (CSDS: males only) or 3 days of sub-threshold variable stress (STVS: females only) conditions in adulthood. Long-lasting transcriptional alterations were assessed in the ventral tegmental area (VTA), nucleus accumbens (NAc), medial prefrontal cortex (PFC), and ventral hippocampus (HIP, males only) in adulthood.
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