Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Glucose metabolism induced chromatin remodeling in pulmonary artery endothelial cell

ABSTRACT: Glucose metabolism induced chromatin remodeling in pulmonary artery endothelial cell

PROVIDER: PRJNA353304 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5014600_1.fastq.gz	Fastqsanger.gz
	SRR5014600_2.fastq.gz	Fastqsanger.gz
	SRR5014610_1.fastq.gz	Fastqsanger.gz
	SRR5014610_2.fastq.gz	Fastqsanger.gz
	SRR5014601_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 44

Similar Datasets

Glucose metabolism induced chromatin remodeling in pulmonary artery endothelial cell [ChIP-Seq]

Project description:Maintaining endothelial cells (EC) as a monolayer in the vessel wall depends on a gene expression profile and the metabolic state, features influenced by contact with neighboring cells eg, pericytes and smooth muscle cells (SMC). Dysfunctional bone morphogenetic protein receptor 2 (BMPR2) signaling disrupts EC metabolism and monolayer formation and is associated with vascular diseases such as pulmonary arterial hypertension. We show that BMPR2 in either EC or SMC is required for contact-dependent activation of Notch1 in EC. Notch1, through the glycolysis inducer PFKFB3, mediates an increase in the citrate pool and histone acetylation required for Notch1 and MYC target gene expression. This maintains Notch1-dependent EC proliferative capacity, coordinating with Notch1 activation of mitochondria. We report how Notch1 and p300 binding to chromatin and H3K27ac status are influenced by glucose metabolism and regulate gene expression in endothelial cells.

2019-03-18 | GSE89786 | GEO

Glucose metabolism induced chromatin remodeling in pulmonary artery endothelial cell [RNA-Seq]

2019-03-18 | GSE89787 | GEO

Effects of BMPR2 Loss in Human Pulmonary Artery Endothelial Cells

Project description:Pulmonary arterial hypertension (PAH) is a fatal disease characterized by a proliferative endothelial cell phenotype, inflammation and pulmonary vascular remodeling. BMPR2 loss-of-function has been linked to pathologic plexiform lesions with obliteration of distal pulmonary arteries distal pulmonary arteries BMPR2 silencing inprimary human pulmonary artery ECs (HPAECs) recapitulate important aspects of cellular dysfunction and deregulated signaling associated with PAH. Primary HPAECs were transfected with gene-specific siRNA pools targeting BMPR2 or control siRNA followed PMA or control stimulation.

2015-12-04 | E-GEOD-70456 | biostudies-arrayexpress

Effects of BMPR2 Loss in Human Pulmonary Artery Endothelial Cells

2015-12-04 | GSE70456 | GEO

Proteomics of CLIC4 overexpressing human pulmonary artery endothelial cells

Project description:To identify CLIC4 effectors by studying proteins expressiosn altered by CLIC4 overexpression in human pulmonary artery endothelial cells.

2018-10-16 | PXD008714 | Pride

Expression data from pulmonary artery endothelial cell after exposure to hypoxia for 24 hours

Project description:A number of mediators that have been found to be involved in the pathogenesis of hypoxic pulmonary hypertension, these mediators including mRNA, microRNAs and long noncoding RNAs. Endothelial dysfunction plays a major role in the initiation of pulmonary vascular remodeling and is thought to be a major contributor to this process. However, mRNA and no-coding RNAs expression profiles and their biological functions in pulmonary artery endothelial cells (PAECs) exposed to hypoxia need to be investigated further. Pulmonary artery endothelial cells (PAECs) were exposed to normoxia condition (21% O2, 5% CO2, 74% N2) or hypoxia condition (3% O2, 5% CO2, 92% N2) (n=3 for each group).PAECs were harvested after 24 hours and performed to further analysis.

2023-09-24 | GSE243567 | GEO

Pulmonary artery banded rat heart

Project description:Changes in juvenile rat heart with pulmonary artery banding

2022-05-20 | PXD027427 | Pride

Glucose metabolism induced chromatin remodeling in pulmonary artery endothelial cell

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-03-18 | GSE89788 | GEO

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging

Project description:To investigate cellular and molecular mechanisms associated with the age-related remodeling observed in the proximal pulmonary artery, we analyzed transcriptomic changes of resident pulmonary arterial cells.

2025-06-10 | GSE299310 | GEO

Apelin/APJ targeted microRNAs in pulmonary artery endothelial cells

Project description:Evaluation of microRNAs that are downstream of apelin/APJ signaling in the pulmonary artery endothelial cells.

2012-12-04 | GSE42343 | GEO