Project description:Our study provides detailed analysis of DF-induced transcriptomes generated by RNA-Seq technology. RNA-Seq based transcriptome analyzes would elucidate complex molecular mechanisms of multi-herbal composition like DF
Project description:Asterids is one of the major plant clades comprising of many commercially important medicinal species. One of the major concerns in medicinal plant industry is adulteration/contamination resulting from misidentification of herbal plants. This study reports the construction and validation of a microarray capable of fingerprinting medicinally important species from the Asterids clade.
2014-07-31 | GSE31242 | GEO
Project description:Detecting the community composition of soil microorganisms
Project description:Echinacea, native to the Canadian prairies and the prairie states of the United States, has a long tradition as a folk medicine for the Native Americans. Currently, Echinacea are among the top 10 selling herbal medicines in the U.S. and Europe, due to increasing popularity for the treatment of common cold and ability to stimulate the immune system. However, the genetic relationships within the species of this genus are unclear, which makes difficult the authentication of the species used for the medicinal industry. We report the construction of a novel Subtracted Diversity Array (SDA) for Echinacea species and demonstrate the potential of this array for isolating highly polymorphic sequences.
2013-12-31 | GSE44683 | GEO
Project description:complete chloroplast genome of herbal plant species
Project description:Abstract Background:Colorectal Cancer (CRC) is a common malignant tumor of the digestive tract, with poor prognosis in advanced stages due to metastasis and immune evasion.Chronic intestinal inflammation may promote CRC progression by inducing an imbalance in the immune microenvironment, thus therapeutic strategies targeting immune regulation urgently need to be explored.Wumei Wan (WMW), a traditional Chinese herbal formula, has shown marked anti-inflammatory activity in ulcerative colitis (UC).However, whether it can inhibit CRC progression remains unclear. Aim:This study aims to investigate whether WMW can ameliorate CRC and to explore its underlying mechanisms. Methods:An AOM/DSS-induced CRC mouse model was established, and transcriptomicss, metabolomics, and network pharmacology analyses were integrated to investigate and validate the mechanisms of WMW. Results:WMW ameliorated CRC progression by improving colonic pathological conditions, lowering Disease Activity Index (DAI) scores, enhancing survival, and suppressing tumor growth in CRC mice. Specifically, the WMW group’s DAI score decreased by approximately 34.36% compared to the model group. Additionally, by day 70, the survival rate in the WMW-treated group was 22.806% higher than that of the model group. Multi-omics and network pharmacology analyses indicated that WMW inhibited the IDO-Kyn-AHR signaling pathway, decreased Th17 and Treg cell proliferation and differentiation, restored CD8+T cell function, and enhanced antitumor immunity. Conclusion：This research demonstrates for the first time that WMW suppresses CRC progression by rebalancing Th17/Treg immunity through modulation of the IDO1-Kyn-AHR pathway.
2025-07-16 | GSE295477 | GEO
Project description:The chloroplast genome project of herbal plant species
Project description:This study aimed to identify transcript expression induced by tonifying herbal medicines (THM) and modes of action (MOA) of THM in A549 cell line. For the production of THM-induced transcripts, tonifying herbal medicines water extract (THW) and tonifying herbal medicines ethanol extract (THE) were used.
Project description:This study aimed to identify transcript expression induced by tonifying herbal medicines (THM) and modes of action (MOA) of THM in A549 cell line. For the production of THM-induced transcripts, tonifying herbal medicines water extract (THW) and tonifying herbal medicines ethanol extract (THE) were used.
