Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rattus norvegicus

ABSTRACT: Effect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing

PROVIDER: PRJNA374533 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR5249544.fastq.gz	Fastqsanger.gz
	SRR5249545.fastq.gz	Fastqsanger.gz
	SRR5249546.fastq.gz	Fastqsanger.gz
	SRR5249547.fastq.gz	Fastqsanger.gz
	SRR5249548.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 6

Similar Datasets

Rattus norvegicus strain:Wistar

Project description:Single cell RNA sequencing analysis of orthodontic tooth movement in rat periodontal ligament

| PRJDB19639 | ENA

Effect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing

Project description:Corticision is a common technique to accelerate orthodontic tooth movement; however, not much is known about the underlying mechanisms. In this study, we investigated the mechanism of alveolar tissue remodeling after corticision in a rat model of tooth movement (TM) by analyzing the differential transcriptome

2018-02-13 | GSE94825 | GEO

single cell RNA sequencing (scRNA-seq) of mouse first molar and adjacent alveolar bone tissues with and without orthodontic loading

Project description:Single-cell RNA sequencing (scRNA-seq) was performed on mouse first molar and adjacent alveolar bone tissues (within 1 mm, buccal and palatal sides). Two groups were analyzed: non-loaded control and orthodontic tooth movement (OTM) after 1 day. The study aims to reveal early cellular and transcriptional changes induced by orthodontic force.

2026-02-09 | GSE309282 | GEO

Transcriptome Profiling of Rattus norvegicus Embryonic Stem Cells by RNA-Sequencing

Project description:In order to establish a rat embryonic stem cell transcriptome, mRNA from rESC cell line DAc8, the first male germline competent rat ESC line to be described and the first to be used to generate a knockout rat model was characterized using RNA sequencing (RNA-seq) analysis.

2016-09-02 | GSE44150 | GEO

Sequencing of Rattus norvegicus synovial fibroblasts

Project description:Knee osteoarthritis (KOA), as a degenerative multifactorial disease, affects the quality of life and mental health of patients, and also brings a huge socioeconomic burden. Treating synovitis have shown promise as anti-inflammatory therapeutics in mitigating OA symptoms and disease progression. Here, by analysing synovial single-cell sequencing (scRNA-seq) data from KOA, we found that synovial fibroblasts (FLS) in OA synovium showed a distinct pro-inflammatory phenotype. We collected synovial tissue from patients with clinical OA as well as from healthy donors, and histological examination was consistent with findings in scRNA-seq. Inspired by recent cross-tissue fibroblast lineage studies, we identified by sequencing that healthy FLS in synovial tissues share transcriptome-level similarities with dermal fibroblasts (DFb). Subsequently, we revealed the local as well as systemic distribution of intra-articular injected DFbs by constructing/extracting two types of rat fibroblasts (luciferase DFbs as well as GFP DFbs). The results demonstrate that DFbs can be locally retained in the synovium for up to three weeks following targeted engrafting on it. And intra-articular injection does not result in DFbs migration to vital organs or the occurrence of histological changes in these organs. A rat model of KOA was constructed by anterior cruciate ligament transection (ACLT) in order to study the therapeutic effect of DFbs on KOA. After injection, the rats showed improvement in painful gait. In addition, histological as well as imaging results showed reduced synovitis and improvement in articular cartilage. Finally we verified the protective effect of DFbs on cytokine-stimulated chondrocytes in a co-culture system.

2026-06-24 | GSE304724 | GEO

Neutrophils Orchestrate Osteoclastogenesis in Orthodontic Tooth Movement

Project description:Neutrophils Orchestrate Osteoclastogenesis in Orthodontic Tooth Movement

| PRJNA1436506 | ENA

Sequencing of Rattus norvegicus chondrocytes under dermal fibroblast co-culture

2026-06-24 | GSE304832 | GEO

Neutrophils Orchestrate Osteoclastogenesis in Orthodontic Tooth Movement

Project description:To elucidate the biological mechanisms of alveolar bone remodeling during orthodontic tooth movement (OTM), we performed single-cell RNA sequencing (scRNA-seq) on periodontal ligament (PDL) tissues from a mouse OTM model. We identified 11 distinct cell clusters and revealed that neutrophils are a primary source of pro-inflammatory cytokines such as TNF, IL-1β, and OSM. Our analysis identified a specific “Inflammatory-Neu” subset that expands during OTM and coordinates macrophage recruitment. This study demonstrates that neutrophils act as indispensable upstream regulators that drive osteoclastogenesis during mechanical loading.

2026-07-10 | GSE324651 | GEO

Identification of candidate immunity biomarkers associated with age-related variations in osteoclast activity following orthodontic tooth movement

Project description:This study provides a comprehensive examination of the influence of age on osteoclast activity during orthodontic tooth movement, analyzed through the lens of osteoimmunology, identifying key immune molecules and cells involved in the regulation.We identified key molecules that play an important role in orthodontic bone reconstruction by analyzing the differences in immune inflammatory differential gene expression across different age groups. These molecules, which facilitate macrophage migration to the local site and their differentiation into osteoclasts, as well as directly enhance osteoclast differentiation and function, are differentially expressed in young groups, but not in adult groups.

2025-08-20 | GSE299315 | GEO

Mass Spectrometry-Based Proteomic Approaches for Salivary Biomarkers in Patients with Fixed Orthodontic Appliances and the Invisalign System: A Non-Randomized Clinical Trial

Project description:Early detection of biological changes is crucial for effective monitoring of orthodontic tooth movement (OTM). Research that elucidates the connection between OTM and proteomic analysis remains limited. This study aimed to identify salivary biomarkers specific to fixed orthodontic appliances (FOA) and Invisalign (IN) treatment modalities.

2026-04-12 | PXD062882 | JPOST Repository

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data