Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transition into inflammatory cancer-associated adipocytes in breast cancer microenvironment requires microRNA regulatory mechanism

ABSTRACT: Transition into inflammatory cancer-associated adipocytes in breast cancer microenvironment requires microRNA regulatory mechanism

PROVIDER: PRJNA378531 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Transition into inflammatory cancer-associated adipocytes in breast cancer microenvironment requires microRNA regulatory mechanism.

Project description: Not available

| S-EPMC5363867 | biostudies-literature

Transition into inflammatory cancer-associated adipocytes in breast cancer microenvironment requires microRNA regulatory mechanism

Project description:This SuperSeries is composed of the SubSeries listed below.

2017-03-09 | GSE95829 | GEO

Cancer-associated adipocytes microRNA

Project description:The role of adipocytes in cancer microenvironment has gained focus during the recent years. However, the characteristics of the cancer-associated adipocytes (CAA) in human breast cancer tissues and the underlying regulatory mechanism are not clearly understood. We reviewed pathology specimens of breast cancer patients to understand the morphologic characteristics of CAA, and profiled the mRNA and miRNA expression of CAA by using indirect co-culture system in vitro.

2017-03-09 | GSE95828 | GEO

Cancer-associated adipocytes mRNA

2017-03-09 | GSE95827 | GEO

Adipocytes are dispensable in shaping the ovarian cancer tumor microenvironment in the omentum

Project description:Adipocytes are dispensable in shaping the ovarian cancer tumor microenvironment in the omentum

| PRJNA1278742 | ENA

SAA1-dependent reprogramming of adipocytes by tumor cells is associated with triple negative breast cancer aggressiveness

Project description:Cancer development and progression depend on tumor cell intrinsic factors, the tumor microenvironment and host characteristics. Despite the identification of the plasticity of adipocytes, the primary breast stromal cells, both in physiology and cancer, we lack a complete understanding of mechanisms that regulate adipocyte-tumor cell crosstalk. Here we dissected the breast cancer crosstalk with adipocytes and studied relevant molecules. We identified that the ability of breast cancer cells to dedifferentiate adipocytes is intrinsic subtype-dependent, with all breast cancer subtypes, except for HER2+ER+ subtype, capable of inducing this phenomenon. Crosstalk between breast cancer cells and adipocytes in vitro increased cancer stem-like features and recruitment of pro-tumorigenic immune cells, through chemokine production. Serum amyloid A1 (SAA1) was in vitro identified as a regulator of the adipocyte dedifferentiation program in triple-negative breast cancer (TNBC) through CD36 and P2XR7 signaling. In human TNBCs, SAA1 expression was associated with CAA infiltration, inflammation, stimulated lipolysis, stem-like properties and distinct tumor immune microenvironment. Our findings provide evidence that interaction between tumor cells and adipocytes through SAA1 release is relevant to the aggressiveness of TNBC, potentially supporting its targeting.

2024-01-15 | PXD041186 | Pride

Adipocytes are dispensable in shaping the ovarian cancer tumor microenvironment in the omentum

Project description:The omentum, a specialized adipose tissue within the peritoneum, is a key metastatic niche for ovarian cancer (OC) dissemination during peritoneal carcinomatosis. The prevailing view is that omental adipocytes promote tumor growth by providinglipids, since global FABP4 deficiency curbs tumor growth. Here, we generated mice lacking mature adipocytes in the peritoneum and omentum. ID8p53–/–Brca2–/– , BPPNM, and KPCA OC cells retained a propensity to seed at regions typically associated with adipocytes, even without mature adipocytes. However, lack of mature adipocytes did not suppress peritoneal OC expansion, whereas removing the adipocyte-free omentum did. Murine and human single-cell RNA sequencing analysis revealed that endothelial FABP4 was high in the omentum. Indeed, endothelial cell-selective deficiency of FABP4 reduced OC growth in the peritoneum. These findings prompt a re-evaluation of adipocyte contributions to OC progression and point to a key role of the omental vasculature in supporting OC growth metabolically.

2026-06-15 | GSE300038 | GEO

RNA-Seq to decipher breast cancer-adipocytes reciprocal reprogramming: evaluating the impact of glucose

Project description:The tumor microenvironment, including adipocytes, is a critical element for breast cancer (BC) progression, also responding to metabolic stimuli characterizing obesity and/or diabetes. The reciprocal reprogramming established between BC cells and adipocytes remains to be deciphered. We investigated (i) the effect of mammary adipocytes on BC cells and vice versa, (ii) the impact of glucose on BC cells, adipocytes and (iii) the impact of glucose on their cross-talk. We have identified adipocyte-modulated genes in BC cells and BC cell-modulated genes in adipocytes, dependently and independently of glucose levels. We identified the adipogenesis process as the most relevantly differentially regulated pathway both in cancer cells and in adipocytes upon exposure to high glucose concentration. Specifically, we observed that BC cells promote de-differentiation of adipocytes and re-shaping toward a fibroblast-like phenotype, particularly upon glucose lowering; the de-lipidation of adipocytes is paralleled by induction of adipogenesis genes in BC cells.

2024-09-19 | GSE243555 | GEO

Effect of 3T3-L1 adipocytes co-culture with MCF7 breast tumor cells.

Project description:In breast cancer, the tumor microenvironment includes adipocytes. When in contact with breast tumor cells, adipocytes undergo lipolysis and dedifferentiation. These changes in the adipocytes support breast tumor cell migration and invasion. This study asseses the changes in gene expression in co-cultured adipocytes and MCF7 cells.

2026-04-09 | GSE273442 | GEO

Genome‐wide analysis reveals miR‐3184‐5p and miR‐181c‐3p as a critical regulator for adipocytes‐associated breast cancer

Project description:The purpose of this study is to identify miRNA expression changes in adipocyte-associated breast cancer microenvironment by using indirect in vitro co-culture system. We performed small RNA small RNA deep sequencing in human breast cancer cells and breast cancer cells co-cultured with mature adipocytes. We identified 98 differentially expressed miRNAs in breast cancer cells co-cultured with adipocytes using small RNA deep sequencing.

2019-08-20 | GSE118342 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data