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Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

ABSTRACT: Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability

PROVIDER: PRJNA379173 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5343780_1.fastq.gz	Fastqsanger.gz
	SRR5343780_2.fastq.gz	Fastqsanger.gz
	SRR5343790_1.fastq.gz	Fastqsanger.gz
	SRR5343790_2.fastq.gz	Fastqsanger.gz
	SRR5343800_1.fastq.gz	Fastqsanger.gz

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Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric trait heritability [RNA-Seq]

Project description:We analyzed differential methylation (via WGBS) between four distinct human brain regions (NAcc-nucleus accumbens, BA9-dorsolateral prefrontal cortex, BA24-anterior cingulate cortex, and HC-hippocampus) in both sorted nuclei and intact tissues. We isolated neuronal and non-neuronal (glial) nuclei from the same six individuals for each tissue via FACS using the neuronal marker, NeuN. Additionally, we performed WGBS from non-sorted tissues from these same brain regions in a total of 12 individuals (BA9 n = 9; BA24 n = 5; HC n = 6; NAcc n = 7). To complement our DNA methylation analyses, we measured gene expression (RNA-seq) and chromatin accessibility (ATAC-seq) in neuronal and non-neuronal nuclei from the nucleus accumbens and dorsolateral prefrontal cortex from six more individuals. We then performed an integrative analysis to understand how the epigenome contributes to brain region-specific function.

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