Fusarium sp.
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA389173 | ENA |
REPOSITORIES: ENA
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| Other | ||||
| SRR5712550.fastq.gz | Fastqsanger.gz | |||
| SRR5712560_1.fastq.gz | Fastqsanger.gz | |||
| SRR5712560_2.fastq.gz | Fastqsanger.gz | |||
| SRR5712551_1.fastq.gz | Fastqsanger.gz |
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Project description:Fusarium graminearum is a major pathogen of Fusarium head blight in wheat, barley, and rice, as well as ear rot and stalk rot in maize. Regulatory Factor X (RFX) transcription factors are well-conserved in animals and fungi, but their functions are diverse, ranging from DNA-damage response to ciliary gene regulation. We investigated the role of the sole RFX transcription factor, RFX1, in F. graminearum. Deletion of rfx1 resulted in multiple defects in hyphal growth, conidiation, virulence, and sexual development. Deletion mutants of rfx1 were more sensitive to various types of DNA damage than the wild-type strain. Septum formation was inhibited and micronuclei were produced in the rfx1 deletion mutants. The results of the neutral comet assay demonstrated that disruption of rfx1 function caused spontaneous DNA double-strand breaks. To understand regulatory mechanisms of rfx1 in F. graminearum, we obtained and analyzed genome-wide transcription profiles generated from the RNA-sequencing data of the wild-type and Δrfx1 strains. RNA-sequencing-based transcriptomic analysis revealed that RFX1 suppressed the expression of many genes, including genes for the repair of DNA damage.
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Project description:The Imitation Switch (ISWI) chromatin remodeling factors are known to form stable remodeling complexes with members from a family of proteins, termed DDT-domain proteins. ISWIs have been reported to be involved in various biological processes in many eukaryotic species. However, the regulatory mechanisms of DDT-domain proteins in ISWI complexes remain unclear. In this study, using ChIP-seq assays, we found that FgDDT binds to the promoter of MAPK and growth-related gene, activating its expression. Moreover, we identified and characterized two additional ISWI genes, FgISW1 and FgISW2, indicating that the ISWI components FgISW1 and FgDDT, rather than FgISW2, are essential for fungal development and virulence. Subsequently, we illustrated that FgDDT binds to FgISW1 to form an ISWI complex that activates the expression of functional genes in Fusarium graminearum, contributing to the virulence and development of F. graminearum. We also we observed that FgDDT is highly conserved in Fusarium species, but exhibits low similarity in Homo sapiens and Arabidopsis thaliana. These findings provide a basis for further studies on the molecular mechanisms by which ISWI complexes function in fungi.
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