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Homo sapiens

ABSTRACT: Polymerase II pausing licenses cell-cycle progression (RNA-Seq)

PROVIDER: PRJNA393890 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR5818150_1.fastq.gz	Fastqsanger.gz
	SRR5818150_2.fastq.gz	Fastqsanger.gz
	SRR5818160_1.fastq.gz	Fastqsanger.gz
	SRR5818160_2.fastq.gz	Fastqsanger.gz
	SRR5818170_1.fastq.gz	Fastqsanger.gz

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Regulation of Mammalian Cell Growth and Survival By an RNA Polymerase II-Pausing Factor (ChIP-seq)

Project description:Many mammalian genes are occupied by paused RNA polymerase II (pol II) at promoter-proximal regions on both sides of transcription start sites (TSSs). However, the consequences of pol II pausing on gene expression and cell biology are not fully understood. Here we report that genetic ablation of the b subunit of mouse negative elongation factor (Nelf-b), a key pol II-pausing factor, results in slower progression at multiple cell cycle stages and increased apoptosis. Consistently, a whole-genome analysis indicates that growth and cell death-related genes are highly enriched among the direct target genes of Nelf-b. In particular, Nelf-b deletion increases pol II density in the promoter-distal region of stress response genes and their overall expression levels in the absence of any external stress signals. In addition, our work also reveals a previously unappreciated role of Nelf-b role in curbing TSS-upstream transcription of many mammalian genes. We suggest that Nelf-mediated pol II pausing balances the cellular needs for growth/survival and stress response by preventing excessive basal transcription of stress-induced genes. Examination of Nelf-b bindings sites on chromosomes in mouse embryonic fibroblasts

2011-08-17 | E-GEOD-24113 | biostudies-arrayexpress

The functional impact of RNA Polymerase II pausing across multiple mamamlian cell types

Project description:We analyzed the breadth and functional relationships of RNA Polymerase II pausing across many human and mouse cell types to understand what roles RNA Polymerase II pausing plays in gene regulation. We identified a novel association of H2A.Z at the TSS of increasingly paused genes. We knocked down H2A.Z to test whether H2A.Z positively or negatively affects RNA Polymerase II pausing to find that pausing globally increased upon knockdown.

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Project description:CDK9-dependent RNA polymerase II pausing controls transcription initiation

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