Project description:This study aimed to delineate molecular phenotypes of the lung microenvironment across idiopathic interestitial pneumonias, namely interstitial pneumonia with autoimmune features (IPAF)and idiopathic pulmonary fibrosis (IPF) through proteomic analysis of bronchoalveolar lavage fluid (BALF).
Project description:Acute Interstitial Pneumonia (AIP) represents a severe form of diffuse lung injury within the idiopathic interstitial pneumonia spectrum. Given the limited understanding of its molecular basis, this study aims to elucidate AIP's transcriptomic profiles to uncover its pathophysiological underpinnings and identify potential therapeutic targets.
2024-12-08 | GSE283072 | GEO
Project description:Molecular phenotyping of the idiopathic interstitial pneumonias identifies two Subtypes of idiopathic pulmonary fibrosis.
Project description:Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive fibrosis of the lung parenchyma. To identify potential therapeutic targets for IPF, we conducted spatial transcriptomic analysis and single-cell RNA sequencing (scRNA-seq). Our findings reveal that PAK plays a critical role in the immature fibroblast niche during fibrogenesis, highlighting its potential as a therapeutic target for the treatment of IPF.
Project description:The goal of this study is to identify downstream pathways, diagnostic markers, and potential therapeutic targets for IFS/CMN. Global gene expression of 14 cellular mesoblastic nephromas/infantile fibrosarcoma was compared with 10 RT, 16 clear cell sarcomas of the kidney, and 15 Wilms tumors using Affymetrix U133A arrays to identify genetic pathways that clarify the pathogenesis of Rhabdoid Tumors and to discover new therapeutic targets for these tumors
Project description:We report abonormally expressed genes of idiopathic interstitial pneumonia by RNA-seq analysis. BMP3 was found down-regulated in idiopathic intestital pneumonia patients, and it closely correlated with pathogenesis of disease. The role of BMP3 in advancement of idiopathic interstitial pneumonia was verified by a series of experiments. Examination of differentially expressed genes in idiopathic interstitial pneumonia. Verification the function of selected gene in pathogenesis of idiopathic interstitial pneumonia in vivo and invitro.
Project description:This study identified informative gene expression signatures in peripheral blood cells that can characterize TAA status and subtypes of TAA. Moreover, a 41-gene classifier based on expression signature can identify TAA patients with high accuracy. The transcriptional programs in peripheral blood leading to the identification of these markers also provide insights into the mechanism of development of aortic aneurysms, and highlight potential targets for therapeutic intervention. The classifier genes identified in this study and validated by TaqMan® real-time PCR assays define a set of promising potential diagnostic markers, setting the stage for a blood-based gene expression test to facilitate early detection of TAA. Keywords: Gene Expression Signature
