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Canagliflozin impact on human renal proximal tubular cells (HK2)

ABSTRACT: Canagliflozin impact on human renal proximal tubular cells (HK2)

PROVIDER: PRJNA415785 | ENA |

REPOSITORIES: ENA

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Canagliflozin impact on human renal proximal tubular cells (HK2)

Project description:The impact of canagliflozin on gene expression changes was investigated in human renal proximal tubular cells (HK2) after pre-treatment with high glucose.

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Expression data from Stx2-treated human renal proximal tubular epithelial cell (RPTEC)

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Transcription profiling by array of human renal proximal tubular cell cultures treated with nephrotoxins

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2011-02-01 | E-MEXP-2599 | biostudies-arrayexpress

Integration of Epigenetic and Transcriptomic Signature reveals Key Transcription Factors involving in Renal Tubular Response to extracellular Stimuli

Project description:To understand the transcription regulation of renal tubular epithelial cells under stimuli, here we investigated transcriptome, chromatin accessibility and their dynamics through RNA-seq and ATAC-seq under the three types of treatments. We identified genome-wide functional regions which coordinated transcription regulation in human renal proximal tubule epithelial cells (HK2). Our results provide a cell type-specific landscape of chromatin dynamics under stimuli and discovered an important TF in renal tubular epithelial cells that mediated genomic response to different injury stimuli.

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Analysis of altered microRNA expression profiles in proximal renal tubular cells in response to calcium oxalate monohydrate crystal adhesion

Project description:The present study aims to assess the potential changes in microRNAs of proximal renal tubular cells in response to the adhesion of calcium oxalate monohydrate (COM) crystals. microRNA microarray was applied to evaluate the expression of HK-2 cells exposed to COM crystals for 0 and 24 hours.

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The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo

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