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High throughput screen identifies novel small molecules that derepress genes repressed by DNA methylation

ABSTRACT: High throughput screen identifies novel small molecules that derepress genes repressed by DNA methylation

PROVIDER: PRJNA417267 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6260970.fastq.gz	Fastqsanger.gz
	SRR6260980.fastq.gz	Fastqsanger.gz
	SRR6260990.fastq.gz	Fastqsanger.gz
	SRR6260971.fastq.gz	Fastqsanger.gz
	SRR6260981.fastq.gz	Fastqsanger.gz

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High throughput screen identifies novel small molecules that derepress genes repressed by DNA methylation

Project description:Genes repressed by DNA methylation can be derepressed by various compounds targeting DNA methyltransferases, histone deacetylases, etc. Here, we report a high throughput screen against a 308,251-member chemical library aiming to identify novel small molecules that derepress an EGFP reporter gene silenced by DNA methylation. RNA-seq was used to measure mRNA abundance in control and compound-treated cells.

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High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility

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High throughput CRISPRi screen identifies viability lncRNAs in human monocytes

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