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Expression data from endothelial cells induced from bone marrow mesenchymal stem cells with SCD1 overexpression

ABSTRACT: Expression data from endothelial cells induced from bone marrow mesenchymal stem cells with SCD1 overexpression

PROVIDER: PRJNA417317 | ENA |

REPOSITORIES: ENA

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Expression data from endothelial cells induced from bone marrow mesenchymal stem cells with SCD1 overexpression

Project description:Bone marrow mesenchymal stem cells (BM-MSCs) are of multi-differentiating potential and has been demonstrated to have the ability to differentiate into endothelial cells. Stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in lipid metabolism, which can convert saturated fatty acids into unsaturated fatty acids. We used lentivirus to transfected SCD1 gene into BM-MSCs and found that overexpression of SCD1 could promote the differentiation of BM-MSCs into endothelial cells. We used microarrays to detect the differential gene expression profile of endothelial induced BM-MSCs with SCD1 overexpression.

2017-11-07 | GSE106596 | GEO

RNAseq analysis of bone marrow mesenchymal stem cells

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Inferferon gamma induced compositional changes in human bone marrow derived mesenchymal stem/stromal cells

Project description:2D IDA protein quantitation of mesenchymal stem cells derived from bone marrow across five donors. A total of 10 2D LC-MS runs were performed, using cells both not stimulated and following a 20 hour treatment with interferon gamma.

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Expression data from rat bone marrow mesenchymal stem cells

Project description:Expression data from rat bone marrow mesenchymal stem cells

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Effects of overexpression of IFI6 in bone marrow mesenchymal stem cells on gene expression profiles of acute lymphoblastic leukemia cells

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Marrow-derived Mesenchymal stem cells(2004/12/24)

Project description:Primary culture of marrow-derived mesenchymal cells vs marrow-derived MSCs with a prolonged life span vs MSCs with a prolonged life span after neuronal induction. Keywords: repeat sample

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Effects of overexpression of IFI6 in bone marrow mesenchymal stem cells on gene expression profiles of acute lymphoblastic leukemia cells

Project description:We explored the effects of high expression of interferon-inducible protein 6 in bone marrow mesenchymal stem cells on the gene expression profiles of acute lymphoblastic leukemia cells.

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RNA sequencing analysis of wild-type and Scd1-deficient CD4+ naïve T cells

Project description:Analysis of differentially expressed genes in Scd1-deficient CD4+ naïve T cells. The goal of this study was to elucidate the underlying pathway of Scd1-deficiency leading to increased regulatory T cell differentiation.

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Expression data in HCT-116 colon cancer cell treated with SCD1 inhibitor or in SCD1 knocked out HCT-116 cell

Project description:To understand molecular mechanisms underlying the growth inhibitory ativity of Stearoyl-CoA desaturase-1 (SCD1) inhibitor, we performed microarray analysis using HCT-116 colorectal cancer cells, in which SCD1 was pharmacologically blocked or genetically ablated.

2017-08-01 | GSE98364 | GEO

Expression data of A939572 SCD1 inhibitor treated ccRCC cells

Project description:Presently, there is a deficiency of effective therapies designed to target clear cell renal cell carcinoma (ccRCC), with poor prognosis resulting in patients with advanced disease. Additionally, there is a lack of molecular factors which can be remedially targeted resulting in tumor specific inhibition, and therefore current therapeutic approaches often produce adverse side effects in patients. We identified that Stearoyl-CoA desaturase 1 (SCD1) was consistently overexpressed in patient ccRCC samples, and further investigation of SCD1 as a potential molecular target for ccRCC intervention utilizing a SCD1 inhibitor (A939572) resulted in tumor specific growth inhibition and induction of cell death. In order to understand the mechanism by which the SCD1 inhibitor mediated its anti-tumor effects, we performed gene array analysis and compared expression patterns between treated and untreated samples. Four established ccRCC cell lines purchased from ATCC were treated with DMSO control versus A939572 over a 24 hour time period. RNA from each group was isolated and sent of for gene array anaylsis. Gene expression data from each individual treatment group was normalized to its respective DMSO contol, and resulting expression patterns associated with drug exposure was compared between the four cell lines.

2012-10-11 | E-GEOD-41485 | biostudies-arrayexpress

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