Project description:Glioblastoma is one of the most malignant brain tumors with poor prognosis and their development and progression are known to be driven by glioblastoma stem cells. Although glioblastoma stem cells lose their cancer stemness properties during cultivation in serum-containing medium, little is known about the molecular mechanisms regulating signaling alteration in relation to reduction of stemness. In order to elucidate the global phosphorylation-related signaling events, we performed a SILAC-based quantitative phosphoproteome analysis of serum-induced dynamics in glioblastoma stem cells established from the tumor tissues of the patient. Among a total of 2,876 phosphorylation sites on 1,584 proteins identified in our analysis, 732 phosphorylation sites on 419 proteins were regulated through the alteration of stem cell characteristics.

2016-01-13 | PXD002614 | Pride

Epigenetic characterization of glioblastoma stem cells

Project description:Epigenetic characterization of glioblastoma stem cells

| PRJNA430732 | ENA

Glioblastoma stem cells after METTL8 knockdown.

Project description:Glioblastoma stem cells after METTL8 knockdown.

| PRJNA788505 | ENA

Glioblastoma stem cells after RNF8 overexpression

Project description:Glioblastoma stem cells after RNF8 overexpression

| PRJNA787899 | ENA