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Tumor-associated macrophages regulate the gene expression profiles of pancreatic cancer cells both under normoxia and hypoxia

ABSTRACT: Tumor-associated macrophages regulate the gene expression profiles of pancreatic cancer cells both under normoxia and hypoxia

PROVIDER: PRJNA429651 | ENA |

REPOSITORIES: ENA

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Tumor-associated macrophages regulate the gene expression profiles of pancreatic cancer cells both under normoxia and hypoxia

Project description:Pancreatic cancer is a devastating and intractable disease with highly lethal rate, which is equal to incidence of the disease.It is well established that tumor microenvironment plays a pivotal role in tumor progression and metastasis.Tumor-associated macrophages (TAMs) are frequently found in close proximity with pancreatic cancer cells, but it is uncertain whether they are involved in pancreatic cancer progression.TAMs around the cancer regions usually exert their tumor-supporting functions by the secretion of cytokines and inflammatory mediators.In this study, we aim to investigate that whether tumor-associated macrophages regulate the gene expression profiles of pancreatic cancer cells both under normoxia and hypoxia.

2018-05-07 | GSE109110 | GEO

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Transcriptomic profiling of wild-type and Bmal1-/- myoblasts under normoxia or actue hypoxia conditions

Project description:Purpose: The goal of this study is to investigate the role of interplay between circadian clock and oxygen-sensing pathways in determining myogenic progenitor cell fate. Methods: Total RNAs were extracted from wild-type and Bmal1-/- myoblasts following exposure to normoxia (21% O2) or hypoxia (1% O2) for 6 hours, and subjected to RNA-sequencing. Results: There were significantly up-regulated (443 in normoxia versus 477 in hypoxia) and down-regulated (745 in normoxia versus 796 in hypoxia) genes in Bmal1-/- cells compared to wild-type, with a large degree of overlap between hypoxia and normoxia, although the fold change of differential gene expression was generally greater under hypoxia versus normoxia. Conclusion: Loss of Bmal1 in myoblasts leads to a premature differentiation-prone transcriptome, which was exaggerated following exposure to hypoxia.

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Mycobacterium tuberculosis normoxia hypoxia reactivation with ActivX-desthiobiotin FP probe

Project description:Lysates of Mycobacterium tuberculosis (H37Rv auxotroph mc(2)6020) grown under various conditions (normoxia, hypoxia, reactivation from hypoxia) probed the serine hydrolase probe with ActivX-desthiobiotin FP.

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Effect of hypoxia and normoxia in Pancreatic Ductal Adenocarcinoma

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