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Mouse Embryo Sox1 cre-dependent knockout of EED

ABSTRACT: Mouse Embryo Sox1 cre-dependent knockout of EED

PROVIDER: PRJNA436234 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6791772.fastq.gz	Fastqsanger.gz
	SRR6791773.fastq.gz	Fastqsanger.gz
	SRR6791774.fastq.gz	Fastqsanger.gz
	SRR6791775.fastq.gz	Fastqsanger.gz
	SRR6791776.fastq.gz	Fastqsanger.gz

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Mouse Embryo Sox1 cre-dependent knockout of EED

Project description:Floxed EED homozygote mice are knocked-out by Sox1-driven Cre to remove H3K27me3 during neurogenesis

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Mouse Embryo E11, E13, E15, E18 conditional knockout of EED, with wt controls

Project description:Floxed EED homozygote mice are knocked-out by Sox1-driven Cre to remove H3K27me3 during neurogenesis

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Project description:Primary rib chondrocyte were isoloated from P0.5-day old wildtype and Col2-Cre:floxed EED conditional knockout mouse pups,and cultured overnight in 10%FCS containing DMEM. RNA was isolated and subjected to Affymetrix Mouse Gene ST 1.0 array. Primary rib chondrocyte were isoloated from P0.5-day old wildtype and Col2-Cre:floxed EED conditional knockout mouse pups,and cultured overnight in 10%FCS containing DMEM. RNA was isolated and subjected to Affymetrix Mouse Gene ST 1.0 array. Biological duplicate. Mice were in a mixed genetic background of C57/B6 and 129sv.

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Mouse Embryo E11, E13, E15, E18 conditional knockout of EED, with wt controls

Project description:Mouse Embryo E11, E13, E15, E18 conditional knockout of EED, with wt controls

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Single cell RNA-seq developmental series in mouse hypothalamus in wild-type and Eed-cKO

Project description:Neuronal sub-type diversity in the hypothalamus is staggeringly immense. To investigate the role of epigenetic regulation in hypothalamic development in the generation of this cellular diversity; a floxed Eed allele was crossed to the early, pan-CNS Cre deleter Sox1-Cre, resulting in loss of H3K27me3 in the entire Mus musculus CNS by E11.5. E12.5, E13.5, E15.5, and E16.5 embryonic mouse hypothalamic cells were dissected and analysed by single cell RNA sequencing, on the Illimina/BioRad platform.

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Gene expression profiling of Eed knockout and Ezh2 knockout small intestinal crypts [RNA-seq]

Project description:Polycomb-mediated gene repression plays an important role in adult stem cell maintenance. We knocked out (using the inducible AhCre-LoxP system) Polycomb genes Eed and Ezh2 in the intestine for 6 weeks, after which crypts - the small intestinal stem cell zone - were harvested and RNA sequenced. We found Wnt, Notch and cell cycle pathways to be affected in Eed knockout (KO) but not Ezh2 KO crypts. Direct targets of Eed were determined by comparing this data with ChIP-sequencing. Small intestinal crypt mRNA profiles of 6 weeks-induced 12 weeks old Eed KO, Ezh2 KO and WT mice (all triplicates) as well as 10 days-induced Eed KO and WT organoids (duplicates) were generated by RNA sequencing over two runs and using IlluminaHiseq2000 and Hiseq2500.

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Gene expression profiling of Eed knockout and Ezh2 knockout small intestinal crypts [RNA-seq]

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Bulk RNA-seq of Colonic Epithelia from EED and EED/Satb2 Double Knockout Mice

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Analysis of changes in gene expression in skin epidermis upon conditional knockout of PRC2-subunit Eed

Project description:Analysis of changes in gene expression in skin epidermis upon conditional knockout of the essential Polycomb repressive complex 2 (PRC2) subunit Eed. Loss of Eed in skin epithelium leads to de-repression of key Merkel-differentiation genes, which are known PRC2 targets, and results in ectopic formation of Merkel cells that are associated with all hair types. Gene expression analysis: To determine the changes in gene expression in skin epidermis upon conditional knockout of Eed, total RNA was isolated from skin epidermis in four biologic replicates from cells in different conditions and hybridized to SurePrint G3 Mouse GE 8X60K microarrays (Agilent).

2016-06-14 | E-GEOD-83244 | biostudies-arrayexpress

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