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Deletion of Lats 1 and 2 in mouse pancreatic acinar cells

ABSTRACT: Deletion of Lats 1 and 2 in mouse pancreatic acinar cells

PROVIDER: PRJNA437647 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6822090.fastq.gz	Fastqsanger.gz
	SRR6822100.fastq.gz	Fastqsanger.gz
	SRR6822091.fastq.gz	Fastqsanger.gz
	SRR6822092.fastq.gz	Fastqsanger.gz
	SRR6822093.fastq.gz	Fastqsanger.gz

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Deletion of Lats 1 and 2 in mouse pancreatic acinar cells

Project description:Mice with adult pancreatic acinar cell–specific deletion of Lats1&2 genes by using CreER/LoxP were generated. Pancreata were collected and profiled using RNA-seq. The RNA-sequencing data identified upregulation of pro-inflammatory and pro-fibrotic genes in Lats1&2 null pancreata, which may play important roles in stimulating PSC activation and promoting pancreatic fibrosis.

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