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RNA-seq of glioma patient tissues treated by DMSO or LY2109761

ABSTRACT: RNA-seq of glioma patient tissues treated by DMSO or LY2109761

PROVIDER: PRJNA437873 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6825140.fastq.gz	Fastqsanger.gz
	SRR6825141.fastq.gz	Fastqsanger.gz
	SRR6825142.fastq.gz	Fastqsanger.gz
	SRR6825139.fastq.gz	Fastqsanger.gz

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Project description:Panobinostat is a non-selective histone deactylase inhibitor which has been approved by FDA for treatment of mutiple myeloma. Whether and how the drug works on glioblastoma remains unclear. Here we treated mice implanted with patient derived xenograft glioblastoma G43 with DMSO or Panobinostat and harvest the tumors for microarray analysis for gene expression results.

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Project description:Purpose: Evaluate transcriptional changes in glioma derived stem cells, U251, and normal human astrocytes following treatment with NH125, Tunicamycin, or 0.1% DMSO Methods: Glioma derived stem cells, U251 and Normal Human Astrocytes were plated in individual dishes and treated with either 2.5 micromolar NH125, 1.0 mcg/mL Tunicamycin, or 0.1% DMSO (vehicle) for twenty-four hours followed by total RNA extraction, library preparation and next generation sequencing Results: Using our analysis pipeline we mapped our sequence reads to the reference genome GRCh38. Following read count normalization and differential expression of NH125 and tunicamycin treated samples to vehicle treated controls we found that NH125 and tunicamycin treatment lead to activation of similar signalling pathways Conclusions: We present an optimized workflow for analysis of transcriptional changes in drug treated glioma derived stem cells, glioblastoma cells and normal human astrocytes

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Gene expression of patient derived xenograft glioblastoma treated with DMSO control or Panobinostat.

Project description:Gene expression of patient derived xenograft glioblastoma treated with DMSO control or Panobinostat.

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