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G-protein coupled receptor kinase 2 safeguards epithelial phenotype in Head and Neck Squamous Cell Carcinomas.

ABSTRACT: G-protein coupled receptor kinase 2 safeguards epithelial phenotype in Head and Neck Squamous Cell Carcinomas.

PROVIDER: PRJNA438594 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR6847150_1.fastq.gz	Fastqsanger.gz
	SRR6847150_2.fastq.gz	Fastqsanger.gz
	SRR6847145_1.fastq.gz	Fastqsanger.gz
	SRR6847145_2.fastq.gz	Fastqsanger.gz
	SRR6847146_1.fastq.gz	Fastqsanger.gz

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G-protein coupled receptor kinase 2 safeguards epithelial phenotype in Head and Neck Squamous Cell Carcinomas.

Project description:Head and neck squamous cell carcinoma (HNSCC) arises from the mucosal lining of the upper aerodigestive tract and display few treatment options in advanced stages. Despite increased knowledge of HNSCC molecular biology, the identification of new players involved in triggering HNSCC recurrence and metastatic disease is needed. We uncover that G-protein-coupled receptor kinase-2 (GRK2) expression is reduced in undifferentiated, high-grade human HNSCC tumors, whereas its silencing in model human HNSCC cells is sufficient to trigger epithelial-to-mesenchymal transition (EMT) phenotypic features, an EMT-like transcriptional program and enhanced lymph node colonization from orthotopic tongue tumors in mice. Conversely, enhancing GRK2 expression counteracts mesenchymal cells traits by mechanisms involving phosphorylation and decreased functionality of the key EMT inducer Snail1. Our results suggest that GRK2 safeguards the epithelial phenotype, whereas its downregulation contributes to the activation of EMT programs in HNSCC

2019-12-31 | GSE111932 | GEO

Gene expression profiling of mir-1825 alteration in Head and neck squamous cell carcinomas

Project description:Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common malignant cancer worldwide. To understand the pathogenesis of HNSCC, we investigated the effects of miR-1825 overexpression on tumor formation capacity of head and neck cancer cells in vivo using NUDE mice. We searched for potential targets of miR-1828 using microarray analysis and luciferase assay. We found that miR-1825 expression is upregulated in head and neck cells and clinical tumor samples in comparison to corresponding controls, where it potentially acts as an oncogene.

2025-07-23 | GSE211921 | GEO

Transcription profiling of human metastasized vs. non-metastasized primary head and neck squamous cell carcinomas

Project description:Gene expression patterns of 11 metastazised tumors of the head and neck region were compared to 11 non-metastasized tumors Experiment Overall Design: 11 metastazised head and neck squamous cell carcinomas from 3 regions (mouth, oropharynx, larynx) were compared to 11 non-metastazised tumors on affymetrix arrays

2008-06-18 | E-GEOD-9349 | biostudies-arrayexpress

Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinomas

Project description:We show that head and neck squamous cell carcinomas models with deficient H3K36me, induced by H3K36M expression, lead to epigenetic dysregulation.

2024-01-02 | GSE222312 | GEO

Transcription profiling of matching human primary head and neck squamous cell carcinomas and cervical lymph node metastases.

Project description:An experiment was performed to investigate the perservation of gene expression upon metastasis of primary head and neck squamous cell carcinomas to the cervical lymph node.

2006-10-23 | E-TABM-114 | biostudies-arrayexpress

Global hypomethylation identifies loci targeted for hypermethylation in head and neck cancer: normal head and neck tissue

Project description:Genome-wide DNA methylation profiling of head and neck squamous cell carcinomas. The Illumina Infinium 27k Human DNA methylation BeadChip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in fresh-frozen tumor tissues. Samples included 91 tumors from the oralpharynx and larynx, reflecting all stages of disease, 18 normal head and neck National Disease Research Interchange (NDRI) samples, and 213 normal control blood samples. Bisulphite-converted DNA from the 18 normal head and neck samples were hybridized to the Illumina Infinium 27k Human Methylation Beadchip v1.2.

2011-10-27 | E-GEOD-25083 | biostudies-arrayexpress

Global hypomethylation identifies loci targeted for hypermethylation in head and neck cancer: normal head and neck tissue

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Gene expression profiles of Head & Neck Squamous and Lung Squamous Cancers

Project description:The differential diagnosis between head & neck squamous cell carcinomas and lung squamous cell carcinomas is often unresolved because the histologic appearance of these two tumor types is similar. In the development of a gene expression profile test (GEP-HN-LS) that distinguishes these 2 cancer types, a collection of poorly differentiated primary and metastatic tumor specimens were used. Here we describe 76 such tumor specimens that were used for validation of GEP-HN-LS. The specimens are either head & neck squamous cell carcinomas or lung squamous cell carcinomas.

2013-03-10 | GSE44170 | GEO

Head and neck squamous cell carcinomas

Project description:This SuperSeries is composed of the following subset Series: GSE11929: Identification of a subgroup of head and neck cancers lacking numerical chromosomal aberrations GSE11931: Copy Number Alterations in HNSCC with or without Oncogene Expressing Human Papillomavirus Refer to individual Series

2009-03-11 | E-GEOD-12020 | biostudies-arrayexpress

scRNA-sequencing from HPV-positive head and neck squamous cell carcinomas

Project description:scRNA-sequencing from HPV-positive head and neck squamous cell carcinomas

| PRJNA725706 | ENA