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Effect of visible light on human skin fibroblasts

ABSTRACT: Effect of visible light on human skin fibroblasts

PROVIDER: PRJNA448517 | ENA |

REPOSITORIES: ENA

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Effect of visible light on human skin fibroblasts

Project description:Artificial visible light is everywhere in our modern life. Our mode of social communication confronts us with screens of all kinds and their use is on the rise. People are therefore increasingly exposed to artificial visible light of which effects on skin are still largely poorly known. The purpose of this study was to model the artificial visible light emitted by electronic devices and subsequently assess the effect of such a light in normal human fibroblasts.

2018-06-30 | GSE112614 | GEO

RNA-seq in normal human dermal fibroblast cells for understanding protective effects of visible red light (660nm) in response to UVB (312nm) exposure

Project description:The aim of this study is identifying potential signaling pathways involve with visible red light induced photoprotective effect against skin damage by UVB exposure, using transcriptomic analysis

2021-06-20 | GSE116968 | GEO

Next Generation Sequencing to identify the expression of transcripts and abnormal events in 3D skin exposed to blue wavelength and full spectrum of visible light

Project description:Samples of 3D skin, irradiated using LED light and compared with un-exposed control, regarding one- and four-days of incubation. Three groups were simulating acute exposure: 1h, 2h and 4 hours whereas the 3D skin samples irradiated for 1 hour over four sequential days were simulating repeated exposure, for both blue wavelength and the full visible spectrum of digital light.

2023-11-28 | GSE190106 | GEO

Effect of visible light on the transcriptome of Clostridium autoethanogenum during gas fermentation

Project description:The expression profile of C. autoethanogenum DSM 10061 grown autotrophically with H2:CO:CO2 under visible light at an intensity of 4200 lux versus the expression profile of C. autoethanogenum DSM 10061 grown autotrophically in the dark

2023-07-01 | GSE207468 | GEO

Effect of visible light on the transcriptome of Clostridium autoethanogenum during gas fermentation

Project description:Effect of visible light on the transcriptome of Clostridium autoethanogenum during gas fermentation

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Bioprinting of Injectable Centimeter-scale Architectures with a Visible-light Crosslinking Bioink

Project description:This study propose a novel visible-light crosslinking hydrogel bioink (termed GP) to fabricate injectable centimeter-scale architectures. Composed of GelMA with large molecular weight PEGDA, GP can form a reinforced dual-crosslinking network, presenting excellent superelasticity and stability, supporting injection pass nozzles with 1.5mm inner diameter after bioprinted as 15mm×15mm scale architectures. Moreover, when printing with living cells, even for sensitive cell lines like genome-edited cells, the transcriptome of cells after printing shows no difference, suggesting the high cell printing suitability of GP and the visible-light extrusion printing technique. The printed architectures can support long-term culture for at least 14 days, and GP provides cells with a biocompatible microenvironment, supporting cell survival, proliferation, and function maintenance.

2023-10-19 | GSE230068 | GEO

Decoding transcriptional regulation in response to visible light in vertebrates

Project description:Decoding transcriptional regulation in response to visible light in vertebrates

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Decoding transcriptional regulation in response to visible light in vertebrates

Project description:Sunlight influences various physiological processes, including circadian clock regulation and DNA repair via D-box enhancer elements. However, the broader transcriptional effects of visible light remain unclear. To investigate this, we compared light-mediated gene expression in zebrafish (Danio rerio) and the blind Somalian cavefish (Phreatichthys andruzzii), a species that evolved in perpetual darkness and lacks light-dependent circadian and DNA repair responses. We performed RNA sequencing of zebrafish and cavefish embryonic cell lines exposed to blue light (468 nm, for up to 6 hours), followed by gene ontology analysis and functional validation via bioinformatic, in vitro, and in vivo approaches. We revealed a light-dependent activation of a set of mitochondrial and heme metabolism genes via D-box enhancer elements. This transcriptional response was absent in cavefish cells. Further analysis revealed that while all zebrafish and cavefish PAR-bZip factors can activate the D-box, cavefish homologs exhibit diminished activity, suggesting an evolutionary reduction in light responsiveness. The D-box emerges as a key regulator of light-driven transcription in zebrafish, extending its role beyond circadian and DNA repair pathways to metabolic and mitochondrial processes. These findings provide insights into the evolution of light-sensing transcriptional mechanisms and lay the groundwork for future studies on their physiological implications.

2025-12-03 | GSE290582 | GEO

Bioprinting of Injectable Centimeter-scale Architectures with a Visible-light Crosslinking Bioink

Project description:Bioprinting of Injectable Centimeter-scale Architectures with a Visible-light Crosslinking Bioink

| PRJNA957298 | ENA

Effect of neutrophil depletion on gene expression im macrophages and fibroblasts from mouse lung and skin

Project description:To investigate the effect of the absence of neutrophils in the transcriptome of fibroblast and macrophage from lung and skin we injected DT to Mrp8 CRE+ iDTR and Mrp8 CRE- iDTR mice every two days for a week and isolated lung and skin fibroblasts and macrophages by cell sorting . We then performed gene expression profiling analysis using data obtained from RNA-seq of macrophages and fibroblast 7 days after DT treatment and compared the transcriptomes of macrophages and fibroblasts in control or neutrophil depletion animals. We focused on the role of neutrophils on the regulation of extracelular matrix genes in fibroblasts and macrophages and found that neutrophil depletion does not significantly affect the RNA level of matrix-related transcripts in those cells.

2025-01-09 | GSE202738 | GEO

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