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Expression data from allergic patients to profilin

ABSTRACT: Expression data from allergic patients to profilin

PROVIDER: PRJNA472340 | ENA |

REPOSITORIES: ENA

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Expression data from allergic patients to profilin

Project description:Prevalence and severity of allergic diseases have increased worldwide. To date, respiratory allergy phenotypes are not fully characterized and, along with inflammation progression, treatment is increasingly complex and expensive. Profilin sensitization constitutes a good model to study the progression of allergic inflammation. We have used microarrays to understand the underlying mechanisms of severe profilin-mediated reactions using a model that includes patients with different levels of sensitization to profilin (non-allergic, mild, moderate and severe)

2018-05-22 | GSE114707 | GEO

Expression data from lymphocytes (CD3+ cells) from severe, mild allergic patients and a non allergic group.

Project description:Expression data from lymphocytes (CD3+ cells) from severe, mild allergic patients and a non allergic group.

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Expression data from lymphocytes (CD3+ cells) from severe, mild allergic patients and a non allergic group.

Project description:The causes underlyed the acquisition and maintainance of a severe allergic phenotype remain unknown. Here, we study the cd3+ complete transcriptomic fingerprint from severity-stratified patients to understand the involvement of these cells in the development of severe allergy. We used microarrays to detail the global programme of gene expression of CD3+ cells from severity-stratified allergic patients

2023-02-02 | GSE224253 | GEO

Expression data from OVA-induced allergic mice

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Expression data from OVA-induced allergic mice [Agilent]

Project description:Expression data from OVA-induced allergic mice [Agilent]

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Expression data from OVA-induced allergic mice [Affymetrix]

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The effects of novel adjuvant complex and CpG ODN on host immune response to recombinant Eimeria profilin vaccine

Project description:This study investigated the ability of two novel adjuvant formulations, QCDC (Quil A/cholesterol/DDA/Carbopol) and QCDCR (QCDC/Bay R1005), in combination with a recombinant profilin vaccine, to modulate host protective immunity and to alter new gene expression during experimental avian coccidiosis. Four-condition experiment, Profilin only vs. Non-vaccination, Profilin only vs. Co-vaccination of QCDC plus profilin, Profilin only vs. Co-vaccination of QCDCR plus profilin, Biological replicates: 2 profilin only replicates, 2 Non-vaccination replicates, 2 QCDC plus profilin replicates, 2 QCDCR plus profilin replicates with dye-switching.

2010-10-28 | E-GEOD-24966 | biostudies-arrayexpress

Mouse embryoid body differentiation in Profilin-2 3'UTR cis-element mutants

Project description:The coordinated actions of post-transcriptional regulation are essential for stem cell differentiation. The Profilin-2 transcript can be targeted by microRNAs and RNA binding proteins, specifically Ago2 and ESCC family of miRNAs -- miR-291-3p/294-3p/295-3p/302-3p -- and the Iron Regulatory Proteins IRP1/2. Earlier studies described the role of the conserved Profilin-2 ESCC miRNA site. This study describes the role of the conserved Profilin-2 IRP/iron-response-element site by CRISPR-mediated disruption of the Profilin-2 3'UTR iron response element site. The transcriptomic data reported indicates impaired germ layer formation and distribution during embryoid body differentiation when compared to wild-type mouse embryonic stem cells.

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BCR sequences in HDM-allergic patients

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Global gene expression of nasal epithelial cells in patients with seasonal allergic rhinitis

Project description:Analysis of nasal epithelial cells from adult patients with seasonal allergic rhinitis and from non allergic controls. Results provide insight into the molecular mechanisms associated with inflammatory responses in nasal mucosa. Total RNA was obtained from nasal epithelial cells of 7 seasonal allergic rhinitis patients and 5 non-allergic control subjects

2015-01-16 | E-GEOD-43523 | biostudies-arrayexpress

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