Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Carbonic anhydrase 13 decreases bone metastasis of iCSCL-10A breast cancer stem cells

ABSTRACT: Carbonic anhydrase 13 decreases bone metastasis of iCSCL-10A breast cancer stem cells

PROVIDER: PRJNA473154 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Carbonic anhydrase 13 decreases bone metastasis of iCSCL-10A breast cancer stem cells

Project description:iRFP713-lebeled iCSCL-10A cells were injected into immunodeficient mice. 5 weeks later, bone metastasized iCSCL-10A cells were extracted from bone marrow was compared with injected cell in vitro culture by microarray and pathway analysis.

2020-05-31 | GSE114942 | GEO

Carbonic anhydrase

Project description:Carbonic anhydrase gene sequence from Cytobacillus oceanisediminis SBA2

| PRJEB98652 | ENA

carbonic anhydrase (1 or 2) simple or double mutants-Comparative transcriptome analysis between carbonic anhydrase mutants and wild type Arabidopsis

Project description:cea05-01_carbonic-anhydrase - carbonic anhydrase (1 or 2) simple or double mutants - Identification of genes differentially expressed in leaves of single CA1 and CA2 T-DNA insertional mutants and in the corresponding double mutant vs wild type - CA1 (At3g01500) and CA2 (At5g14740) T-DNA insertional mutant lines, the double (CA1+CA2) mutant and wild type Arabidopsis seeds were sown in soil in a phytotron. Leaves were harvested 40 days later for RNA extraction

2012-03-25 | GSE36625 | GEO

carbonic anhydrase (1 or 2) simple or double mutants-Comparative transcriptome analysis between carbonic anhydrase mutants and wild type Arabidopsis

2012-03-25 | E-GEOD-36625 | biostudies-arrayexpress

Alveolar macrophages inhibit emphysematous pathology via expression of carbonic anhydrase 4.

Project description:Chronic obstructive pulmonary disease (CODP) including emphysema affects approximately 400 million individuals worldwide. Therapies to treat COPD remain limited and fail to prevent disease progression. Alveolar macrophages (AMs) reside in the alveoli of the lung and are ideally positioned to encounter inhaled particles and pathogens. Despite exposure to these stimuli, AMs exhibit specialized phenotypes that restrict inflammation to prevent alveolar damage. Here we demonstrate that AMs express high levels of the surface bound enzyme carbonic anhydrase 4 (Car4). Deletion of Car4 on AMs results in increased susceptibility to emphysematous pathology and therapeutic treatment with Car4 is sufficient to prevent emphysema-like disease. Consistent with our murine studies, reduced levels of Carbonic anhydrase 4 (CAIV) distinguishes COPD patients with emphysema from those without emphysema. Mechanistically, murine and human Car4 directly inhibit elastase that promotes destruction of alveolar walls. Collectively, these studies reveal an underappreciated function for Car4 in preventing lung pathology.

2026-03-23 | GSE298037 | GEO

Global transcriptomic changes following elevated carbon dioxide (5%) in the wild-type (WT) and mutant (M2; RNAi-knockdown line of carbonic anhydrase (CA2)) Nannochloropsis oceanica IMET1: Illumina sequencing

Project description:In Nannochloropsis oceanica IMET1, transcript knockdown of a cytosolic carbonic anhydrase (CA2; g2018) specifically inhibited by HC resulted in ~45%, ~30% and ~40% elevation of photosynthetic oxygen evolution rate, growth rate and biomass accumulation rate under high CO2 (5% ), respectively. This CA2-knockdown mutant is demonated as M2. To probe mechanistic links underlying the mutant (M2; RNAi-knockdown line of carbonic anhydrase (CA2)) phenotypes, temporal transcriptomic profiles are compared between RNAi-knockdown line of carbonic anhydrase (CA2) and WT, at 12 h and 24h under high CO2 (5%).

2020-10-28 | GSE115445 | GEO

Transcriptome profiling of Arabidopsis thaliana PsbS and β-carbonic anhydrase overexpression lines in response to bicarbonate fertilization

Project description:Photosynthetic efficiency and stress tolerance in plants are regulated by complex interactions between photoprotective mechanisms and carbon metabolism. The photosystem II subunit PsbS plays a central role in non-photochemical quenching, while β-carbonic anhydrases contribute to CO₂ conversion and pH homeostasis in chloroplasts. To investigate the potential crosstalk between these components, we performed RNA-seq analysis of Arabidopsis thaliana lines overexpressing PsbS alone or in combination with β-carbonic anhydrase genes (βCA1 and βCA2). Wild-type (Col-0), the npq4 mutant, and transgenic overexpression lines were grown under controlled conditions and treated either with water or bicarbonate fertilization. Transcriptome profiling was performed using Illumina NovaSeq sequencing of poly(A)+ RNA libraries prepared from total RNA. The dataset contains three biological replicates for each genotype and treatment combination. These data provide insight into transcriptional responses associated with altered PsbS and β-carbonic anhydrase activity and bicarbonate-induced signaling, and can be used to explore regulatory networks linking photoprotection, carbon metabolism, and stress responses in plants.

2026-03-21 | GSE325023 | GEO

RNA-Seq analysis of Oryza sativa, ssp. japonica, cv. Kitaake leaves from plants lacking carbonic anhydrase in the chloroplast

Project description:The aim of this experiment was to assess the impact on the transcriptome of relocalisaiton of carbonic anhydrase activity from the chloroplast to the cytosol in Oryza sativa, ssp. japonica, cv. Kitaake. Four genome edited lines and one wil-type control line were analysed.

2024-06-10 | E-MTAB-14111 | biostudies-arrayexpress

Carbonic Anhydrase 12 is a Novel Prognostic Biomarker and Therapeutic Target for High-Risk Follicular Thyroid Cancer

Project description:Identifying high-risk follicular thyroid cancer (FTC) is critical for stratified treatment and developing targeted therapies. This study performed RNA sequencing on high-risk FTC, identifying Carbonic Anhydrase 12 (CA12) as a promising biomarker. High CA12 expression predicted poor disease-free survival, surpassing conventional markers. In vitro, CA12 knockdown reduced proliferation and invasion, while a CA12 inhibitor showed synergistic anti-proliferative effects with Lenvatinib. These findings establish CA12 as both a novel prognostic biomarker and a potential therapeutic target for FTC.

2026-01-14 | GSE305211 | GEO

Alveolar macrophages inhibit emphysematous pathology via expression of carbonic anhydrase 4.

Project description:Alveolar macrophages inhibit emphysematous pathology via expression of carbonic anhydrase 4.

| PRJNA1267136 | ENA