Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNAseq of laser captured spinal and oculomotor neurons in post mortem material of ALS patients

ABSTRACT: RNAseq of laser captured spinal and oculomotor neurons in post mortem material of ALS patients

PROVIDER: PRJNA473843 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7256880.fastq.gz	Fastqsanger.gz
	SRR7256881.fastq.gz	Fastqsanger.gz
	SRR7256872.fastq.gz	Fastqsanger.gz
	SRR7256882.fastq.gz	Fastqsanger.gz
	SRR7256873.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 14

Similar Datasets

RNAseq of laser captured spinal and oculomotor neurons in post mortem material of ALS patients

Project description:Gene expression profiles of specific neuronal populations might explain differential vulnerability to neurodegeneration in the lethal disease amyotrophic lateral sclerosis (ALS). Using laser capture microscopy (LCM) and RNA sequencing (LCM-seq), we demonstrate that the molecular signature of degeneration-resistant oculomotor neurons (OMNs) is distinct from that of vulnerable spinal motor neurons (MNs).

2020-02-14 | GSE115130 | GEO

RNA-seq of laser captured oculomotor, cervical and lumbar spinal motor, and Onufs nucleus motor neurons in post mortem material of control human subjects

Project description:Oculomotor neurons, which regulate eye movement, are resilient to degeneration in the lethal motor neuron disease amyotrophic lateral sclerosis (ALS). It would be highly advantageous if motor neuron resilience could be modeled in vitro. Towards this goal, we generated a high proportion of oculomotor neurons from mouse embryonic stem cells through temporal overexpression of Phox2a in neuronal progenitors. We demonstrate, using electrophysiology, immunocytochemistry and RNA sequencing, that in vitro generated neurons are bona fide oculomotor neurons based on their similarity to their in vivo counterpart in rodent and man. We also show that in vitro generated oculomotor neurons display a robust activation of survival-promoting Akt signaling and are more resilient to the ALS-like toxicity of kainic acid than spinal motor neurons. Thus, we can generate bona fide oculomotor neurons in vitro which display a resilience similar to that seen in vivo.

2019-05-09 | GSE93939 | GEO

laser-captured chondrocyte transcriptomes from cranial base

Project description:laser-captured chondrocyte transcriptomes from cranial base

| PRJNA1051145 | ENA

RNA sequencing of laser captured hippocampal deep and superficial CA1 subfields in epilepsy

Project description:We profiled total mRNA of laser captured microdissected hippocampal deep and superficial CA1 subfields from adult male (45-50 days) Wistar rats (Rattus norvegicus) (180-200g) subjected to kainic acid-induced status epilepticus (chronic epileptic phase) and control animals.

2021-05-28 | GSE143555 | GEO

Gene Expression Analysis of Laser Captired Purkinje Cells from the Post-Mortem Essential Tremor Cerebellum

Project description:RNA-seq evaluation of enriched Purkinje cells from the post-mortem human cerebellum. Purkinje cells were removed via laser capture microdissection and pooled for RNA-extraction and sequencing. 24 ET patients and 16 controls healthy age matched were compared.

2023-02-28 | GSE197345 | GEO

RNA-seq of Laser Captured Microdissected high-grade serous ovarian tumors

Project description:RNA-seq of Laser Captured Microdissected high-grade serous ovarian tumors

| PRJNA546125 | ENA

Effect of Ovarian Hormone on Gene Expression in Laser Captured Serotonin Neurons from Monkeys

Project description:Ovariectomized monkeys were treated with placebo, estrogen or estrogen plus progesterone for one month. The brain was perfused with RNA Later plus 20% sucrose. Sections through the dorsal raphe nucleus were immunostained for TPH and then TPH positive neurons were laser captured. The RNA was extracted and hybridized to the Rhesus Affymetrix chip.

2009-05-21 | GSE16169 | GEO

Transcriptional profiling of laser captured intestinal tissue from the planarian Schmidtea mediterranea

Project description:Transcriptional profiling of laser captured intestinal tissue from the planarian Schmidtea mediterranea

| PRJNA558547 | ENA

Transcriptional profiling of laser captured gonadal tissue from the planarian Schmidtea mediterranea

Project description:Transcriptional profiling of laser captured gonadal tissue from the planarian Schmidtea mediterranea

| PRJNA790629 | ENA

Homo sapiens

Project description:RNA-seq of laser captured oculomotor, cervical and lumbar spinal motor, and Onufs nucleus motor neurons in post mortem material of control human subjects

| PRJNA362871 | ENA

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data