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Transcriptome profiling of MDA-MB-231 cells following the MEL-18 phosphorylation at T334

ABSTRACT: Transcriptome profiling of MDA-MB-231 cells following the MEL-18 phosphorylation at T334

PROVIDER: PRJNA475547 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7289750_1.fastq.gz	Fastqsanger.gz
	SRR7289750_2.fastq.gz	Fastqsanger.gz
	SRR7289751_1.fastq.gz	Fastqsanger.gz
	SRR7289751_2.fastq.gz	Fastqsanger.gz
	SRR7289752_1.fastq.gz	Fastqsanger.gz

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Transcriptome profiling of MDA-MB-231 cells following the MEL-18 phosphorylation at T334

Project description:RNA-sequencing analysis of MEL-18 WT- or MEL-18 T334A-overexpressing MDA-MB-231 cell lines. MEL-18, a core component of polycomb-repressive complex (PRC)-1, has been known to be phosphorylated at multiple residues in vitro; however, its functional roles in mammalian cells and human cancer remains largely unknown. Here, we examined the effect of MEL-18 phosphorylation at T334 site on polycomb-mediated epigenetic silencing in human breast cancer. Our results demonstrated that the phosphorylation of MEL-18 at T334 alters its genomic distribution and transcriptional activity that reflects functional change of MEL-18 in modulating breast tumour progression.

2022-03-01 | GSE115591 | GEO

Genome-wide binding of phosphorylated MEL-18 protein at T334 in MDA-MB-231 cells

Project description:ChIP-seq analysis of MEL-18 WT- or MEL-18 T334A-overexpressing MDA-MB-231 cell lines. MEL-18, a core component of polycomb-repressive complex (PRC)-1, has been known to be phosphorylated at multiple residues in vitro; however, its functional roles in mammalian cells and human cancer remains largely unknown. Here, we examined the effect of MEL-18 phosphorylation at T334 site on polycomb-mediated epigenetic silencing in human breast cancer. Our results demonstrated that the phosphorylation of MEL-18 at T334 alters its genomic distribution and transcriptional activity that reflects functional change of MEL-18 in modulating breast tumour progression.

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The miRNA profiling in MDA-MB-231, MDA-MB-231/E1A and knockdown of Dicer in MDA-MB-231/E1A cells

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Expression profiles of MDA-MB-231, MDA-231 S1a and S1b

Project description:Identification of genes that are involved in self-seeding by comparing gene expression profiles between parental MDA-MB-231 cells and seeder cells (MDA-231-S1a and S1b) 2 replicates from each sample (parental MDA-MB-231, MDA-MB-231 S1a and MDA-MB-231 S1b) were analyzed

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