Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [BrainMet_Othotopic]

ABSTRACT: Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [BrainMet_Othotopic]

PROVIDER: PRJNA475786 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR7297813.fastq.gz	Fastqsanger.gz
	SRR7297814.fastq.gz	Fastqsanger.gz
	SRR7297815.fastq.gz	Fastqsanger.gz
	SRR7297816.fastq.gz	Fastqsanger.gz
	SRR7297817.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 5

Similar Datasets

Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis

Project description:Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis

| PRJNA475780 | ENA

Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [BrainMet_SQ_2D]

Project description:Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [BrainMet_SQ_2D]

| PRJNA475787 | ENA

Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [MultiDisease]

Project description:Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [MultiDisease]

| PRJNA475788 | ENA

Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [MultiDisease]

Project description:We report that well-defined xenograft models of leading sources of CNS metastasis (melanoma, breast cancer, lung cancer) undergo specific transcriptomic alterations upon entering the brain microenvironment. This dataset can be utilized to explore the mechanisms of tumor cell plasticity as well as the co-adaptation of the brain microenvironment to metastatic disease.

2019-04-08 | GSE115701 | GEO

Transcriptomic Hallmarks of Tumor Plasticity and Stromal Interactions in Brain Metastasis.

Project description:The brain is a major site of relapse for several cancers, yet deciphering the mechanisms of brain metastasis remains a challenge because of the complexity of the brain tumor microenvironment (TME). To define the molecular landscape of brain metastasis from intact tissue in vivo, we employ an RNA-sequencing-based approach, which leverages the transcriptome of xenografts and distinguishes tumor cell and stromal gene expression with improved sensitivity and accuracy. Our data reveal shifts in epithelial and neuronal-like lineage programs in malignant cells as they adapt to the brain TME and the reciprocal neuroinflammatory response of the stroma. We identify several transcriptional hallmarks of metastasis that are specific to particular regions of the brain, induced across multiple tumor types, and confirmed in syngeneic models and patient biopsies. These data may serve as a resource for exploring mechanisms of TME co-adaptation within, as well as across, different subtypes of brain metastasis.

| S-EPMC6592283 | biostudies-literature

Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [BrainMet_SQ_2D]

Project description:We find that malignant LUAD tumor cells grown in the brain microenvironment display significantly altered transcriptomic profiles when compared to tumor cells grown in monolayer or subcutaneously. Additionally, we characterize the reciprocal neuroinflammatory response of the surrounding brain stroma to metastatic LUAD. This dataset can be utilized to explore the mechanisms of LUAD cell plasticity as well as the co-adaptation of the brain microenvironment to metastatic disease.

2019-04-08 | GSE115700 | GEO

Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [BrainMet_Othotopic]

2019-04-08 | GSE115699 | GEO

Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-04-08 | GSE115702 | GEO

Leptin as a Mediator of Tumor-Stromal Interactions Promotes Breast Cancer Stem Cell Activity

Project description:Breast cancer stem cells (BCSCs) play crucial roles in tumor initiation, metastasis and resistance to anticancer therapies. These cells rely for their properties on complex interactions with the tumor microenvironment through networks of cytokines and growth factors. In this study, we investigated how leptin, as a mediator of tumor-stromal interactions, may affect BCSC activity using breast cancer cell lines and patient-derived samples. Microarray analyses revealed a similar expression profile of genes involved in stem cell biology in mammosphere cells treated with stromal cell-CM and leptin.

2015-12-17 | E-MTAB-3641 | biostudies-arrayexpress

Mitochondrial RNA modifications shape metabolic plasticity in metastasis

Project description:Mitochondrial RNA modifications shape metabolic plasticity in metastasis

| PRJNA833944 | ENA