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Single cell RNA sequencing of aortic CD45+ cells and foam cells from atherosclerotic aorta

ABSTRACT: Single cell RNA sequencing of aortic CD45+ cells and foam cells from atherosclerotic aorta

PROVIDER: PRJNA477843 | ENA |

REPOSITORIES: ENA

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Single cell RNA sequencing of aortic CD45+ cells and foam cells from atherosclerotic aorta

Project description:In atherosclerosis, several immune cells are involved in plaque formation. Foam cell formation is a major cellular process in atherosclerotic lesion. It is important to understand which cells participate in foam cell formation. To characterize the immune cells and foam cells in atherosclerotic aorta, we performed single cell RNA sequencing of aortic CD45+ leukocytes from Ldlr-/- mice and foamy cells from ApoE-/- mice. The single cell RNA-seq analyses revealed the heterogeneity of aortic macrophages and foam cells in atherosclerotic aorta.

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