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Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

ABSTRACT: Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

PROVIDER: PRJNA487779 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR7751560_1.fastq.gz	Fastqsanger.gz
	SRR7751560_2.fastq.gz	Fastqsanger.gz
	SRR7751561_1.fastq.gz	Fastqsanger.gz
	SRR7751561_2.fastq.gz	Fastqsanger.gz
	SRR7751523_1.fastq.gz	Fastqsanger.gz

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Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

| PRJNA487781 | ENA

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

Project description:Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

| PRJNA487777 | ENA

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [origins]

Project description:Purpose: The purpose is to systemically identify RNA expression between skin mast cells with distinct origins. Methods: We profiled RNA-seq in skin mast cells with distinct origins. Results: Early, late EMP and fetal HSC-derived skin mast cells display distinct transcriptome profiles.

2018-10-05 | GSE119016 | GEO

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors [development]

Project description:Purpose: The purpose is to systemically identify RNA expression changes along mast cell development during embryogenesis. Methods: We profiled RNA-seq in early EMPs and their progeny. Results: Fetal MCPs acquire the mast cell-specific gene signature from E11.5 and complete their maturation in peripheral tissues.

2018-10-15 | GSE119017 | GEO

Adult Connective Tissue-Resident Mast Cells Originate from Late Erythro-Myeloid Progenitors

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-10-09 | GSE119018 | GEO

Human connective tissue mast cell proteome

Project description:Mast cells are hematopoietic cells that reside preferentially in tissues exposed to internal and external environments. Mast cells sense immunological, inflammatory and environmental stimuli, and can be activated to release granules and generate inflammatory mediators. Mast cell-derived products confer protection against snake venoms and some parasite infections. Aberrant activation of mast cells is a major contributor to human pathology, including allergy, asthma and adverse drug reactions. Their strict tissue location has largely impeded the isolation of large numbers of primary mast cell for further analysis. To better understand the biology of mast cells, we analyzed the proteome of primary human and mouse mast cells by quantitative mass spectrometry. We identified a mast cell-specific protein signature that was conserved from mouse to man. Compared to a comprehensive set of other immune cell lineages, proteome analysis identified a unique and distant mast cell cluster. The mast cell signature included proteins governing granule biosynthesis and secretion, as well as proteoglycan- and neurotransmitter metabolism. Proteome conservation across species suggests evolutionary maintenance of mast cell functions.

2020-02-12 | PXD014978 | Pride

Mouse connective tissue mast cell proteome

2020-02-12 | PXD015040 | Pride

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors.

Project description:Most haematopoietic cells renew from adult haematopoietic stem cells (HSCs), however, macrophages in adult tissues can self-maintain independently of HSCs. Progenitors with macrophage potential in vitro have been described in the yolk sac before emergence of HSCs, and fetal macrophages can develop independently of Myb, a transcription factor required for HSC, and can persist in adult tissues. Nevertheless, the origin of adult macrophages and the qualitative and quantitative contributions of HSC and putative non-HSC-derived progenitors are still unclear. Here we show in mice that the vast majority of adult tissue-resident macrophages in liver (Kupffer cells), brain (microglia), epidermis (Langerhans cells) and lung (alveolar macrophages) originate from a Tie2(+) (also known as Tek) cellular pathway generating Csf1r(+) erythro-myeloid progenitors (EMPs) distinct from HSCs. EMPs develop in the yolk sac at embryonic day (E) 8.5, migrate and colonize the nascent fetal liver before E10.5, and give rise to fetal erythrocytes, macrophages, granulocytes and monocytes until at least E16.5. Subsequently, HSC-derived cells replace erythrocytes, granulocytes and monocytes. Kupffer cells, microglia and Langerhans cells are only marginally replaced in one-year-old mice, whereas alveolar macrophages may be progressively replaced in ageing mice. Our fate-mapping experiments identify, in the fetal liver, a sequence of yolk sac EMP-derived and HSC-derived haematopoiesis, and identify yolk sac EMPs as a common origin for tissue macrophages.

| S-EPMC5997177 | biostudies-literature

C-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages

Project description:Although classified as hematopoietic cells, tissue-resident macrophages are selfrenewing and maintained independently of adult hematopoiesis. While most macrophages originate from embryonic precursors that seed tissues prior to birth, their exact origin is unknown. Using an in utero macrophage depletion strategy and fatemapping of yolk sac (YS) and fetal liver (FL) hematopoiesis, we found that YS macrophages are the main precursors of microglia, while most other macrophages derive from fetal monocytes. Both YS macrophages and fetal monocytes arise from erythro-myeloid progenitors (EMP) generated in the YS. In the YS, EMP gave rise to macrophages without monocytic intermediates, while EMP seeding the FL upon the establishment of blood circulation acquired c-Myb expression and gave rise to fetal monocytes that then seed embryonic tissues to differentiate into macrophages. Thus, adult tissue-resident macrophages established from HSC-independent embryonic precursors arise from two different developmental programs. 12 samples of progenitors, monocytes or macrophages are analyzed from 2 to 4 replicate. Each replicate derived from at least 5 embryos or adult mice

2015-04-23 | E-GEOD-66970 | biostudies-arrayexpress

Expression data from mouse mast cell progenitors, mature mast cells and innate lymphoid cells of type 2

Project description:Mast cells originate from the bone marrow and develop into c-kit+ FcεRI+ cells. As both mast cell progenitors and mature mast cells express these cell surface markers, ways validated to distinguish between the two maturation forms with flow cytometry have been lacking. We identified and sorted two distinct populations of mast cells from mouse peritoneum. Gene expression microarray analyses were used to confirm the maturation statuses of the mast cell populations.

2015-03-07 | GSE63507 | GEO

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