Project description:Outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in the neonatal intensive care unit of a university hospital in Japan
| PRJDB20266 | ENA
Project description:Klebsiella pneumoniae in neonatal intensive care unit
Project description:Methicillin-resistant Staphylococcus aureus (MRSA) infections result in more than 200,000 hospitalizations and 10,000 deaths in the United States each year and remain an important medical challenge. To better understand the transcriptome of Staphylococcus aureus USA300 NRS384, a community-acquired MRSA strain, we have conducted an RNA-Seq experiment on WT samples.
Project description:Methicillin-resistant Staphylococcus aureus is one of the major causative agents associated to infections with a high morbidity and mortality in hospitals worldwide. In previous studies, we reported that lignan 3'-demethoxy-6-O-demethylisoguaiacin isolated and characterized from Larrea tridentata showed the best activity towards methicillin-resistant S. aureus. Understanding of mechanism of action of drugs allows design drugs in a better way. Therefore, we employed microarray to obtain gene expression profile of methicillin-resistant S. aureus after exposure to 3'-demethoxy-6-O-demethylisoguaiacin. The results showed that lignan had an effect on cell membrane affecting proteins of the ATP-binding cassette (ABC) transport system causing bacteria death.
2015-06-27 | GSE70309 | GEO
Project description:third-generation cephalosporin-resistant Enterobacteriaceae in a neonatal intensive care unit
| PRJNA954276 | ENA
Project description:Fatal cases of mecA-positive methicillin-resistant Staphylococcus sciuri infections in a veterinary intensive care unit, Brazil
