Transcriptomics,Genomics

Dataset Information

153

RNA-seq of Wildtype Staphylococcus aureus USA300 NRS384


ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) infections result in more than 200,000 hospitalizations and 10,000 deaths in the United States each year and remain an important medical challenge. To better understand the transcriptome of Staphylococcus aureus USA300 NRS384, a community-acquired MRSA strain, we have conducted an RNA-Seq experiment on WT samples. Overall design: RNA-Seq analysis was performed on log phase WT Staphylococcus aureus USA300 NRS384 grown at 30 degrees C and grown at 37 degrees C. Each condition was performed in triplicate thereby yielding a total of 6 samples for RNA-Seq analysis.

INSTRUMENT(S): Illumina HiSeq 2500 (Staphylococcus aureus USA300-0114)

SUBMITTER: Mark McCreary  

PROVIDER: GSE102279 | GEO | 2017-11-15

SECONDARY ACCESSION(S): PRJNA397207

REPOSITORIES: GEO

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Publications

Host-derived fatty acids activate type VII secretion in Staphylococcus aureus.

Lopez Michael S MS   Tan Irene S IS   Yan Donghong D   Kang Jing J   McCreary Mark M   Modrusan Zora Z   Austin Cary D CD   Xu Min M   Brown Eric J EJ  

Proceedings of the National Academy of Sciences of the United States of America 20171002 42


The type VII secretion system (T7SS) of Staphylococcus aureus is a multiprotein complex dedicated to the export of several virulence factors during host infection. This virulence pathway plays a key role in promoting bacterial survival and the long-term persistence of staphylococcal abscess communities. The expression of the T7SS is activated by bacterial interaction with host tissues including blood serum, nasal secretions, and pulmonary surfactant. In this work we identify the major stimulator  ...[more]

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