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GR mutation in mice changes the genome-wide epigenome of placental tissue in a highly sex-specific manner

ABSTRACT: GR mutation in mice changes the genome-wide epigenome of placental tissue in a highly sex-specific manner

PROVIDER: PRJNA507786 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8268860.fastq.gz	Fastqsanger.gz
	SRR8268870.fastq.gz	Fastqsanger.gz
	SRR8268861.fastq.gz	Fastqsanger.gz
	SRR8268871.fastq.gz	Fastqsanger.gz
	SRR8268862_1.fastq.gz	Fastqsanger.gz

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GR mutation in mice changes the genome-wide epigenome of placental tissue in a highly sex-specific manner

Project description:We found that the GR mutation leads to a complete change of the DNA methylation landscape in fetal placenta of c57/bl6n mice in a highly sex-specific manner. The genome-wide capture-sequencing analysis revealed enrichments in genes related to a broad range of biological functions associated with basic signaling pathways and neurological development, but also with diseases like diabetes and dementia. Furthermore, we showed that the methylation status of certain genes in fetal placenta tissue predicts/is significantly correlated with anxiety of these animals in adulthood. These possible biomarkers could be used as diagnostic tools in the easily available placental tissue at birth allowing primary prevention for children at high risk at the earliest possible point of time in the future.

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GR mutation in mice changes the genome-wide epigenome of frontal cortex in a highly sex-specific manner

Project description:GR mutation in mice changes the genome-wide epigenome of frontal cortex in a highly sex-specific manner

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GR mutation in mice changes the genome-wide epigenome of frontal cortex in a highly sex-specific manner

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Prenatal Exposure to Metals Alters the Placental Inflammatory Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns

Project description:Prenatal exposure to toxic metals is associated with altered placental function and adverse health outcomes. The underlying mechanisms linking in utero toxic metal exposures with later-in-life health remain unclear, though placental inflammation is posited as a potential driver. The aim of this study was to evaluate whether in utero metals presence is associated with sex-specific changes in placental protein expression. We hypothesized that sex-specific patterns of metal-associated placental protein expression would be observed, and metals presence would be positively associated with the altered expression of inflammation-associated pathways Using samples banked from the Extremely Low Gestational Age Newborn Study (ELGAN), umbilical cord tissue samples were analyzed via ICP-MS/MS for trace elements, and placental samples underwent a global untargeted proteomics analysis via LC-MS/MS. This work highlights the linkage between prenatal metals exposure and an altered placental proteome, revealing that metals in cord tissue were associated with largely distinct differences in placental protein expression, in a sexually-dimorphic manner.

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