Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage

ABSTRACT: VD3-VDR axis regulates the homeostasis and function of alveolar macrophage

PROVIDER: PRJNA513268 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8403150.fastq.gz	Fastqsanger.gz
	SRR8403160.fastq.gz	Fastqsanger.gz
	SRR8403151.fastq.gz	Fastqsanger.gz
	SRR8403161.fastq.gz	Fastqsanger.gz
	SRR8403152.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 21

Similar Datasets

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [ChIP-Seq]

Project description:Purpose: To understand the regulation of gene expression of alveolar macrophages by VD3-VDR axis

2019-01-08 | GSE124722 | GEO

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [RNA-Seq]

Project description:Purpose: To understand the regulation of gene expression of alveolar macrophages by VD3-VDR axis

2019-01-08 | GSE124724 | GEO

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [RNA-Seq LPS]

Project description:Purpose: To understand the regulation of gene expression of alveolar macrophages by VD3-VDR axis

2019-01-08 | GSE124723 | GEO

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [ChIP-Seq]

Project description:VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [ChIP-Seq]

| PRJNA513264 | ENA

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [RNA-Seq]

Project description:VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [RNA-Seq]

| PRJNA513272 | ENA

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [RNA-Seq LPS]

Project description:VD3-VDR axis regulates the homeostasis and function of alveolar macrophage [RNA-Seq LPS]

| PRJNA513265 | ENA

VD3-VDR axis regulates the homeostasis and function of alveolar macrophage

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-01-08 | GSE124725 | GEO

Transcriptome of ESCs upon VD3 treatment (+/-) MLL1 inhibition

Project description:This study describes the transcriptome profiling of: 1) Mll1fl/fl mESCs in LIF/Serum medium as control; 2) VD3 and MM-401 (Mll1i) treated mESCs in LIF/serum medium ; 2) VD3 treated mESCs in LIF/serum medium.

2019-12-02 | GSE131297 | GEO

Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function.

Project description:Pulmonary alveolar proteinosis (PAP) results from a dysfunction of alveolar macrophages (AMs), chiefly due to disruptions in the signaling of granulocyte macrophage colony-stimulating factor (GM-CSF). We found that mice deficient for the B lymphoid transcription repressor BTB and CNC homology 2 (Bach2) developed PAP-like accumulation of surfactant proteins in the lungs. Bach2 was expressed in AMs, and Bach2-deficient AMs showed alterations in lipid handling in comparison with wild-type (WT) cells. Although Bach2-deficient AMs showed a normal expression of the genes involved in the GM-CSF signaling, they showed an altered expression of the genes involved in chemotaxis, lipid metabolism, and alternative M2 macrophage activation with increased expression of Ym1 and arginase-1, and the M2 regulator Irf4. Peritoneal Bach2-deficient macrophages showed increased Ym1 expression when stimulated with interleukin-4. More eosinophils were present in the lung and peritoneal cavity of Bach2-deficient mice compared with WT mice. The PAP-like lesions in Bach2-deficient mice were relieved by WT bone marrow transplantation even after their development, confirming the hematopoietic origin of the lesions. These results indicate that Bach2 is required for the functional maturation of AMs and pulmonary homeostasis, independently of the GM-CSF signaling. WT (n=8) and Bach2KO (n=3) AMs. One expreriment was performed.

2014-01-15 | E-GEOD-54050 | biostudies-arrayexpress