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MiRNAs were involved in the radioresistance of esophageal squamous cell carcinoma

ABSTRACT: miRNAs were involved in the radioresistance of esophageal squamous cell carcinoma

PROVIDER: PRJNA513486 | ENA |

REPOSITORIES: ENA

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miRNAs were involved in the radioresistance of esophageal squamous cell carcinoma

Project description:Cancer cells associated with radioresistance are likely to give rise to local recurrence and distant metastatic relapse. However, it remains unclear whether specific miRNAs have direct roles in radioresistance and/or prognosis. In this study, we performed a human miRNA expression array analysis to identify miRNAs upregulated or downregulated in the radioresistant cells. To confirm the results, we selected several candidate miRNAs according to the fold change and function of miRNAs, and detected their expression levels in the radioresistant cells and their parental cells using qRT-PCR. Moreover, we further investigate that specific miRNAs predicts pathological response to preoperative radiotherapy in locally advanced ESCC

2025-01-01 | GSE124784 | GEO

Expression analysis of miRNA involved in radioresistance of oral squamous cell carcinoma.

Project description:Oral squamous cell carcinoma (OSCC) is not significant improved in prognosis despite advancement in treatments. The presence of treatment resistant OSCC is responsible for stagnation in the survival rate. The inter-cellular communications between tumor cells is one of the molecular mechanisms involved in the acquisition of treatment resistance of OSCC. Extracellular vesicles (EVs) and encapsulated miRNAs are important mediators of the inter-cellular communication. We searched for miRNAs involved in radioresistance of OSCC, in order to elucidate the mechanism of acquisition of radioresistance

2021-04-02 | GSE160122 | GEO

Amphiregulin and Epiregulin confer radioresistance in esophageal squamous cell carcinoma through oxidative phosphorylation

Project description:Neoadjuvant chemoradiotherapy combines surgery has been the standard of care for locally advanced esophageal squamous cell carcinoma (ESCC) patients. However, up to 30-50% of nCRT patients can achieve pathological complete response (pCR) and long-term survival, while a considerable number of patients experience short-term recurrence or even progression disease. Therefore, to find out the biomarkers which can better and accurate predict chemoradiation efficacy and understanding the hidden mechanism is still urgently needed. Herein, we found that mitochondrial oxidative phosphorylation (OXPHOS) was involved in radioresistance of nCRT in ESCC patients. CEBPB/AREG/EREGE axis was responsible to affect radiosensitivity through OXPHOS. Either target mitochondrial OXPHOS or ERBB signal pathway effectively enhanced the radiosensitivity for ESCC cells. This study demonstrated the underlying mechanism for AREG/EREG/ERBB regulated OXPHOS involved in ESCC radiosensitivity and provided more opportunities to target vulnerable processes to improve ESCC radiation efficacy for clinic treatment.

2026-02-11 | GSE293873 | GEO

Expression analysis of miRNA involved in radioresistance of oral squamous cell carcinoma.

Project description:Expression analysis of miRNA involved in radioresistance of oral squamous cell carcinoma.

| PRJNA671876 | ENA

Amphiregulin and Epiregulin confer radioresistance in esophageal squamous cell carcinoma through oxidative phosphorylation

Project description:Amphiregulin and Epiregulin confer radioresistance in esophageal squamous cell carcinoma through oxidative phosphorylation

| PRJNA1246634 | ENA

Microarray expression profile of microRNAs in Esophageal Squamous Cell Carcinoma

Project description:The purpose of this study is to explore the miRNAs expression profiles from esophageal squamous cell carcinoma (ESCC) and matched normal adjacent tissue.

2022-02-11 | GSE145198 | GEO

Microarray expression profile of micro RNAs in serum for Esophageal Squamous Cell Carcinoma

Project description:The purpose of this study is to explore the miRNAs expression profiles in the serum from esophageal squamous cell carcinoma (ESCC) patients.

2019-02-07 | GSE112840 | GEO

Gene expression in normal and tumoral esophageal squamous cell lines

Project description:This study was designed to identify genes aberrantly expressed in esophageal squamous cell carcinoma (ESCC) cells. Three esophageal squamous cell carcinoma-derived cell lines and one normal human esophageal squamous cell line were analyzed.

2014-09-20 | E-GEOD-61587 | biostudies-arrayexpress

Gene expression profiles of esophageal squamous cell carcinoma cell lines

Project description:Profiles of esophageal squamous cell carcinoma and normal esophageal normal epithelium normal cell line. Analysis provides validation of novel microRNA targets prediction algorithms. esophageal squamous cell carcinoma:14, normal epithelium cell:2

2016-09-01 | E-GEOD-23964 | biostudies-arrayexpress

The expression profiles of miRNAs in H. pylori infected esophageal cells were analyzed by microarray

Project description:H.pylori colonization in esophageal mucosa increases the expression of CDX2 and COX-2 and exacerbates inflammation of the lower esophagus. However, the regulatory mechanisms have not been clearly defined.To investigate the effect of chronic repeated exposure of H.pylori on esophageal squamous epithelial cells in an in vitro model. To screen the microRNA profiles associated with H.pylori infection in esophageal epithelial cells, and to investigate the regulatory mechanisms of miRNAs on COX-2 and CDX2.The expression profiles of miRNAs in H. pylori infected cells were analyzed by microarray. To confirm the validity of the results, the significantly altered miRNAs were identified by quantitative RT-PCR. The potential targets of miRNAs were screened using Targetscan.

2018-05-05 | E-MTAB-5809 | biostudies-arrayexpress

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