Unknown,Transcriptomics,Genomics,Proteomics

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The expression profiles of miRNAs in H. pylori infected esophageal cells were analyzed by microarray

ABSTRACT: H.pylori colonization in esophageal mucosa increases the expression of CDX2 and COX-2 and exacerbates inflammation of the lower esophagus. However, the regulatory mechanisms have not been clearly defined.To investigate the effect of chronic repeated exposure of H.pylori on esophageal squamous epithelial cells in an in vitro model. To screen the microRNA profiles associated with H.pylori infection in esophageal epithelial cells, and to investigate the regulatory mechanisms of miRNAs on COX-2 and CDX2.The expression profiles of miRNAs in H. pylori infected cells were analyzed by microarray. To confirm the validity of the results, the significantly altered miRNAs were identified by quantitative RT-PCR. The potential targets of miRNAs were screened using Targetscan.

ORGANISM(S): Homo sapiens

SUBMITTER: Guigen Teng

PROVIDER: E-MTAB-5809 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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