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The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy

ABSTRACT: The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy

PROVIDER: PRJNA521609 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8554930_1.fastq.gz	Fastqsanger.gz
	SRR8554930_2.fastq.gz	Fastqsanger.gz
	SRR8554921_1.fastq.gz	Fastqsanger.gz
	SRR8554921_2.fastq.gz	Fastqsanger.gz
	SRR8554931_1.fastq.gz	Fastqsanger.gz

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The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy

Project description:Analyses of the effect of CRISPR/CAS9 mediated knock out of the EMT-transcription factor SNAI2 on the mRNA expression profile of human neuroblastoma SH-SY5Y cells to identify genes that are differentially expressed upon loss of SNAI2. Results provide insight into genes that are repressed by SNAI2 in neuroblastoma cells under normal culture conditions, where loss of SNAI2 enhances the expression of genes involved in biological processes such as neuron development and neuron differentiation.

2020-01-06 | GSE126332 | GEO

Snai2 maintains bone marrow niche cells by repressing osteopontin expression

Project description:Bone marrow (BM) mesenchymal stem and progenitor cells (MSPCs) are a critical constituent of the hematopoietic stem cell (HSC) niche. Previous studies have suggested that the zinc-finger epithelial-mesenchymal transition transcription factor Snai2 (also known as Slug) regulated HSCs autonomously. Here, we show that Snai2 expression in the BM is restricted to the BM stromal compartment where it regulates the HSC niche. Germline or MSPC-selective Snai2 deletion reduces the functional MSPC pool, their mesenchymal lineage output, and impairs HSC niche function during homeostasis and after stress. RNA-sequencing analysis revealed that Spp1 (osteopontin) expression is markedly upregulated in Snai2-deficient MSPCs. Genetic deletion of Spp1 in Snai2-deficient mice, rescues MSPCs’ functions. Thus, SNAI2 is a critical regulator of the transcriptional network maintaining MSPCs by the suppression of osteopontin expression.

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SNAI2

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Project description:Rattus norvegicus Snai2, snail family transcriptional repressor 2 [Source:RGD Symbol;Acc:3722], is differentially expressed in 26 experiment(s);

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Project description:Sus scrofa SNAI2, snail family transcriptional repressor 2 [Source:VGNC Symbol;Acc:VGNC:98330], is differentially expressed in 3 experiment(s);

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SNAI2

Project description:Macaca mulatta SNAI2, snail family transcriptional repressor 2 [Source:VGNC Symbol;Acc:VGNC:81576], is expressed in 3 baseline experiment(s);

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