Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: N-nitrosodimethylamine (NDMA) Formation and Mitigation in Potable Reuse Treatment Trains Employing Ozone and Biofiltration

PROVIDER: PRJNA521999 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR8571160_1.fastq.gz	Fastqsanger.gz
	SRR8571160_2.fastq.gz	Fastqsanger.gz
	SRR8571161_1.fastq.gz	Fastqsanger.gz
	SRR8571161_2.fastq.gz	Fastqsanger.gz
	SRR8571156_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Project description:N-nitrosodimethylamine (NDMA) Formation and Mitigation in Potable Reuse Treatment Trains Employing Ozone and Biofiltration

| PRJNA488258 | ENA

Microbial community characterization of ozone-biofiltration systems in drinking water and potable reuse applications

Project description:Microbial community characterization of ozone-biofiltration systems in drinking water and potable reuse applications

| PRJEB22574 | ENA

Phosphoproteomic response in nitrosamine-exposed mice

Project description:The aim of this study was to characterize ATM/ATR substrate motif specific phosphoproteome (phospho-SQ/TQ) in response to N-nitrosodimethylamine (NDMA) in mice. Motif specific phosphorylation were measured using quantitative LC-MS/MS based on TMT labeling.

2021-02-10 | PXD021142 | Pride

Bulk RNA-seq of juvenile mouse liver following NDMA or saline treatment in WT and Mgmt-/- genotypes across multiple timepoints

Project description:Transcriptomic profiling of mouse liver tissue to characterize the acute and long-term gene expression response to the carcinogen N-nitrosodimethylamine (NDMA) in juvenile mice. RaDR+/+;GPT+/+ (WT) and RaDR+/+;GPT+/+;Mgmt-/- (Mgmt knockout) mice received intraperitoneal injections of NDMA (3.5 mg/kg at postnatal day 8 and 7 mg/kg at postnatal day 15) or saline vehicle. Liver tissue was collected at Day 1, Day 2, Day 5, Week 10, and Month 10 post-treatment and subjected to bulk RNA-seq to identify differential gene expression patterns across genotypes, sexes, treatments, and timepoints.

2026-05-22 | GSE332646 | GEO

Spatial transcriptomics profiling of NDMA-induced liver injury in Mgmt-deficient mice across sex and time

Project description:Spatial transcriptomics (10x Genomics Visium) was performed on fresh-frozen liver tissue (left lobe) from Mgmt-/- mice treated with N-nitrosodimethylamine (NDMA) or saline vehicle during the juvenile period. The study includes male and female mice sacrificed at 10 weeks or 10 months post-birth to characterize spatially resolved transcriptomic changes associated with NDMA-induced liver damage and potential carcinogenesis over time. Mice carried the RaDR+/+; GPT+/+ genotype enabling detection of recombination and mutation events. Tissue sections were processed using the 10x Visium workflow, H&E stained, imaged, permeabilized for spatially barcoded cDNA synthesis, and sequenced on an Illumina NextSeq 500.

2026-05-22 | GSE332601 | GEO

Project description:Microbial Community Characterization in Advanced Water Reclamation for Potable Reuse

| PRJNA749122 | ENA

Project description:Microbial communities in an advanced water treatment system for potable reuse

| PRJNA1086902 | ENA

An Investigation into the Biological Effects of Indirect Potable Reuse Water Using Zebrafish Embryos

Project description:An Investigation into the Biological Effects of Indirect Potable Reuse Water Using Zebrafish Embryos

| PRJNA638388 | ENA

ozone-derived oxisterols impair lung macrophage phagocytosis via adduction of phagocytosis receptors

Project description:Inhalation of the amibient air polution ozone causes lung inflammation and can suppress host defense mechanisms, including impairing macrophage phagocytosis. Ozone reacts with cholesterol in the lung to form oxysterols, like secosterol A and secosterol B, which can form covalent adducts on cellular proteins. How oxysterol-protein adduction modifies the function of lung macrophages is unknown. Herein, we used a preoteomic screen to identify lung macrophage proteins that fomr adducts with ozone-derived oxysterols. Analysis show that the phagocytic receptor CD206 and CD64 formed adducts with secosterol A. Adduction of these receptors with ozone-derived oxysterols impaired ligand binding and corresponded with reduced macrophage phagocytosis. This work suggests a novle mechanism for the suppression of macrophage phagocytosis following ozone exposure through the generation of oxysterols and the formation of oxysterol-protein adducts on phagocytic receptors.

2020-07-18 | PXD019317 | Pride

Oncogenic changes and EMT in normal human bile duct epithelial cells are caused by parasite-derived materials and N-nitrosodimethylamine

Project description:A total of 1,301 differentially expressed genes were identified: 521 upregulated and 780 downregulated. Furthermore, p21 and PAI levels decreased, which coincided with decreases in E-cadherin and increases in fibronectin expression, in cells stimulated with Clonorchis sinensis excretory/secretory products (ESPs) and NDMA. Cancer-related proteins, such as EGFR, K-ras, and PCNA, were significantly upregulated in cells exposed to C. sinensis ESPs and NDMA. Our results showed that C. sinensis ESPs and a small amount of NDMA were sufficient to induce cancerous transformation and epithelial-mesenchymal transition (EMT) in normal H69 cholangiocytes.

2019-10-14 | GSE138806 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data