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MRNA profiling of injured mouse livers with MycER activation

ABSTRACT: mRNA profiling of injured mouse livers with MycER activation

PROVIDER: PRJNA526533 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8710340.fastq.gz	Fastqsanger.gz
	SRR8710350.fastq.gz	Fastqsanger.gz
	SRR8710341.fastq.gz	Fastqsanger.gz
	SRR8710342.fastq.gz	Fastqsanger.gz
	SRR8710333.fastq.gz	Fastqsanger.gz

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mRNA profiling of injured mouse livers with MycER activation

Project description:This study explore the role of the Myc oncogene in liver injury, in particular for the determination of the cellular programme involved in tissue repair and normalization after injury, a process that is blocked by Myc deregulation. The first objective of this study is to define the transcriptional profile of mouse livers 12 days after injury with or without MycER activation. The second objective is to determine the trancriptionl signature at 1,2,3,7 days after MycER was inactivated in pre injured liver to monitor its normalization.

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RNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.

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Project description:Aim: To determine RNA expression levels in heart tissues of mice 4 and 48 hours post Myc activation. Mice were systemically infected with a cardiomyocyte specific adeno associated virus (AAV9) at 4 to 6 weeks of age. Hearts were isolated from adult mice that had been infected with AAV9-Ccnt1 and were either Myh6-cre;R26CAG-c-MycERT2/+ or R26CAG-c-MycERT2/+ following 4 hours of MycER activation via administration of (Z)-4-hydroxytamoxifen. Hearts were isolated from adult mice that had been infected with either AAV9-Ccnt1 or AAV9-RFP and were R26CAG-c-MycERT2/+ 48 hours post a single injection of tamoxifen to induce MycER activity.

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